Comparison of Sevoflurane, Propofol, and Sevoflurane Plus Propofol for Maintenance of Anaesthesia

Phase 4 Completed 90 enrolled Huazhong University of Science and Technology

RandomizedParallel-groupTriple-blindTreatment

Summary

Postoperative pain may be affected by general anaesthetics. The effect of propofol and sevoflurane on postoperative pain in chinese female patients has not been demonstrated before. This study compared the postoperative pain score in patients under general anaesthesia maintained with propofol,sevoflurane, or sevoflurane+propofol.

Timeline

Start: 2009-09
Primary completion: 2010-01
Completion: 2010-01

Publications

Results Li M, Mei W, Wang P, Yu Y, Qian W, Zhang ZG, Tian YK. Propofol reduces early post-operative pain after gynecological laparoscopy. Acta Anaesthesiol Scand. 2012 Mar;56(3):368-75. doi: 10.1111/j.1399-6576.2011.02603.x. Epub 2011 Dec 23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Propofol	Small molecule	2 mg/kg	—
Subject	Propofol	Small molecule	6 mg/kg	—
Subject	Propofol	Small molecule	8 mg/kg	—
Subject	Sevoflurane	Other / unclassified	0.7 unknown	—
Subject	Sevoflurane	Other / unclassified	1.3 unknown	—
Background	Remifentanil	Small molecule	0.1 ug/kg	—
Background	Remifentanil	Small molecule	0.2 ug/kg	—

Indications

No indication recorded.