RituxiMab INDuction in Renal Transplantation

Summary

Hypothesis: * That B cell depletion, rather than reducing acute rejection, will allow minimisation of immunosuppression, which may lead to better graft survival. Aim: * To assess whether the addition of rituximab to a low-dose tacrolimus immunosuppression regime allows a reduction in steroid administration. Objectives: * To assess whether B cell depletion affects graft function, acute rejection and complication rates * To assess whether the T cell response to allotransplantation is impaired by B cell depletion.

Timeline

Start

2010-11

Primary completion

2020-10

Completion

2022-10

Drugs

Indications

No indication recorded.