drugset / Trial / NCT01146834
Trial of Three Stem Cell Mobilization Regimens for Multiple Myeloma
Phase 3
Completed
47 enrolled
Weill Medical College of Cornell University
Millennium Pharmaceuticals, Inc. · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
This phase III randomized trial compares three different peripheral stem cell mobilization regimens for patients with multiple myeloma who have received primary induction therapy or other therapies. Up to 180 patients will be enrolled. Patients eligible for treatment will be randomized to one of the three following mobilization regimens: Arm A = VELCADE, CYCLOPHOSPHAMIDE, \& G-CSF Arm B = VELCADE \& G-CSF Arm C = CYCLOPHOSPHAMIDE \& G-CSF Arm D = PLERIXAFOR \& G-CSF Arm E = PLERIXAFOR, VELCADE, \& G-CSF
Timeline
- Start
- 2011-03
- Primary completion
- 2019-02-04
- Completion
- 2019-02-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bortezomib | Small molecule | 1.3 mg/m2 | Intravenous |
| Subject | Cyclophosphamide | Other / unclassified | 2 g | — |
| Subject | Plerixafor | Small molecule | — | — |
| Background | filgrastim | Protein / enzyme biologic | 10 ug/kg | — |