Drugs / Plerixafor
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Plerixafor

also known as mozobil · AMD3100 · GZ316455

Small molecule targets CXCL12, CXCR4 via inhibition

Developed for
plasma cell myeloma · non-Hodgkin lymphoma · acute myeloid leukemia · Hodgkins lymphoma · sickle cell disease · disease related to hematopoietic stem cell transplant · myelodysplastic syndrome · B-cell chronic lymphocytic leukemia
+43 more · chronic lymphocytic leukemia/small lymphocytic lymphoma · acute lymphoblastic leukemia · adult acute lymphoblastic leukemia · bone marrow failure syndrome · chronic myeloid leukemia · gliosarcoma · Fanconi anemia · lymphoma · malignant pancreatic neoplasm · oligodendroglial tumor · acute leukemia of ambiguous lineage · acute respiratory distress syndrome · adult glioblastoma · anaplastic astrocytoma · anaplastic oligoastrocytoma · anaplastic oligodendroglioma · Asherman syndrome · brain neoplasm · chronic granulomatous disease · colorectal cancer · COVID-19 · diabetes mellitus · infertility disorder · leukemia · limb ischemia · liver failure · mixed neuronal-glial tumor · neuroblastoma · neutropenia · ovarian serous adenocarcinoma · pancreatic adenocarcinoma · precursor lymphoblastic lymphoma/leukemia · refractory plasma cell neoplasm · sarcoma · severe combined immunodeficiency · therapy related acute myeloid leukemia and myelodysplastic syndrome · transplant rejection · type 1 diabetes mellitus · uterine disorder · Wiskott-Aldrich syndrome · dysgammaglobulinemia · myeloid hemopathy · viral infectious disease
Investigated by
Genzyme, a Sanofi Company · Sanofi · National Cancer Institute (NCI) · St. Jude Children's Research Hospital · Washington University School of Medicine · AnorMED
+89 more · Ensoma · M.D. Anderson Cancer Center · Weill Medical College of Cornell University · Assistance Publique - Hôpitaux de Paris · Brigham and Women's Hospital · Case Comprehensive Cancer Center · City of Hope Medical Center · Dana-Farber Cancer Institute · Duke University · Emory University · Federal Research Institute of Pediatric Hematology, Oncology and Immunology · Fred Hutchinson Cancer Center · Millennium Pharmaceuticals, Inc. · Proteonomix, Inc. · URC-CIC Paris Descartes Necker Cochin · 4Living Biotech · Acute Leukemia French Association · Alberta Innovates Health Solutions · Alessandra Biffi · American Association for Cancer Research · CCTU- Cancer Theme · CIBERER · CIEMAT · CRUK Cambridge Institute · Cambridge University Hospitals NHS Foundation Trust · CancerCare Manitoba · Cardiff University · Celgene Corporation · Celldex Therapeutics · Cellex Gesellschaft für Zellgewinnung mbH Dresden · Cellex Gesellschaft für Zellgewinnung mbH Köln · Center for International Blood and Marrow Transplant Research · Children's Healthcare of Atlanta · Conselho Nacional de Desenvolvimento Científico e Tecnológico · David Rizzieri, MD · Doris Duke Charitable Foundation · E. Steve Woodle · EuroFancolen · Experimental Cancer Medicine Centres · French Innovative Leukemia Organisation · Genetix Biotherapeutics Inc. · Gian Paolo Fadini · Hospital Israelita Albert Einstein · Hospital Universitari Vall d'Hebron Research Institute · Hospital Universitario Dr. Jose E. Gonzalez · Hugh Taylor · Insel Gruppe AG, University Hospital Bern · Lawrence D Recht · Lawrence Recht · Leukaemia Lymphoma Research · Lustgarten Foundation · Masonic Cancer Center, University of Minnesota · Massachusetts General Hospital · Mayo Clinic · Memorial Sloan Kettering Cancer Center · Mitchell Horwitz, MD · National Heart, Lung, and Blood Institute (NHLBI) · National Institute for Health Research, United Kingdom · National Institute of Allergy and Infectious Diseases (NIAID) · National Institute of Medical Sciences and Nutrition Salvador Zubiran · National Marrow Donor Program · New York Blood Center · Numoda · PETHEMA Foundation · Patrick Y. Wen, MD · Peking University · Sanofi-Synthelabo · Seattle Children's Hospital · Sheba Medical Center · Shi, Patricia, M.D. · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Stand Up To Cancer · Surbhi Sidana, MD · Technical University Dresden · all 95 on the full record

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved EU (EMA) Mozobil — 2009-07-30 europa.eu ↗
Approved US (FDA) MOZOBIL — 2008-12-15 fda.gov ↗

Trials 102 · started per year

today
US approved 2008
EU approved 2009
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2004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT05343572 Nov 2023 → Dec 2026 expected Asherman syndrome, infertility disorder, uterine disorder Hugh Taylor Recruiting No outcome recorded
Phase 124 trials
Phase 1 NCT07585136 Nov 2026 → Dec 2028 expected bone marrow failure syndrome St. Jude Children's Research Hospital Recruiting No outcome recorded
Phase 1 NCT03932864 Apr 2019 → Feb 2020 — Ensoma Completed No outcome recorded
Phase 1 NCT03664830 Sep 2018 → Jul 2027 expected sickle cell disease City of Hope Medical Center Active not recruiting No outcome recorded
Phase 1 NCT03226691 Jul 2017 → Feb 2019 sickle cell disease National Heart, Lung, and Blood Institute (NHLBI) Completed No outcome recorded
Phase 1 NCT03277209 Jul 2017 → Dec 2019 malignant pancreatic neoplasm Weill Medical College of Cornell University Terminated No outcome recorded Stop: Enrollment
Phase 1 NCT02989701 Jan → Dec 2017 sickle cell disease Alessandra Biffi Completed No outcome recorded
Phase 1 NCT02179970 Jun 2015 → Dec 2018 colorectal cancer, ovarian serous adenocarcinoma, pancreatic adenocarcinoma CCTU- Cancer Theme Completed No outcome recorded
Phase 1 NCT02193191 Sep 2014 → Mar 2025 sickle cell disease Memorial Sloan Kettering Cancer Center Completed No outcome recorded
Phase 1 NCT01916577 Aug 2013 → Oct 2017 chronic obstructive pulmonary disease, cystic fibrosis, pulmonary fibrosis University of Colorado, Denver Completed No outcome recorded
Phase 1 NCT01610999 Jul 2013 → Jun 2014 B-cell chronic lymphocytic leukemia, plasma cell myeloma Tufts Medical Center Terminated No outcome recorded
Phase 1/215 trials · 2 met primary
Phase 1/2 NCT07341022 Jun 2026 → Dec 2027 expected sickle cell disease Hospital Israelita Albert Einstein Not yet recruiting No outcome recorded
Phase 1/2 NCT05470491 Jan 2023 → Jul 2027 expected HIV infectious disease, hematopoietic and lymphoid cell neoplasm National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 1/2 NCT03182426 Aug 2017 → Jul 2024 type 1 diabetes mellitus University of Alberta Completed No outcome recorded
Phase 1/2 NCT02678533 Feb 2017 → Nov 2018 Fanconi anemia Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 1/2 NCT02212535 Jan 2016 → Apr 2017 sickle cell disease Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 1/2 NCT02522572 Aug 2015 → Sep 2020 — E. Steve Woodle Unknown No outcome recorded
Phase 1/2 NCT01977677 Nov 2014 → Nov 2017 adult glioblastoma, adult medulloblastoma, adult pineoblastoma, ependymoblastoma +4 Lawrence Recht Completed No outcome recorded
Phase 1/2 NCT01288573 Mar 2014 → May 2017 brain neoplasm, neuroblastoma, sarcoma Genzyme, a Sanofi Company Completed Met primary
Phase 1/2 NCT01435343 Jul 2012 → May 2016 acute myeloid leukemia PETHEMA Foundation Completed No outcome recorded
Phase 1/2 NCT01280955 Dec 2011 → Sep 2014 bone marrow failure syndrome Mitchell Horwitz, MD Completed Met primary
Phase 248 trials · 2 met primary
Phase 2 NCT07188090 Oct 2025 → Dec 2027 expected Hodgkins lymphoma, non-Hodgkin lymphoma, plasma cell myeloma Thomas Jefferson University Recruiting No outcome recorded
Phase 2 NCT06872333 Nov 2024 → Jun 2030 expected disease related to hematopoietic stem cell transplant, sickle cell disease Masonic Cancer Center, University of Minnesota Recruiting No outcome recorded
Phase 2 NCT06141304 Sep 2023 → Jan 2025 acute myeloid leukemia, adult acute lymphoblastic leukemia The First Hospital of Jilin University Unknown No outcome recorded
Phase 2 NCT04817345 Apr 2023 sickle cell disease St. Jude Children's Research Hospital Withdrawn No outcome recorded Stop: Enrollment
Phase 2 NCT05411575 Jul → Oct 2022 COVID-19, acute respiratory distress syndrome 4Living Biotech Withdrawn No outcome recorded Stop: Enrollment
Phase 2 NCT05445128 Jun → Dec 2022 sickle cell disease Ensoma Terminated No outcome recorded Stop: Business
Phase 2 NCT04762875 Jun → Sep 2021 acute lymphoblastic leukemia, acute myeloid leukemia, myelodysplastic syndrome Ensoma Terminated No outcome recorded Stop: Business
Phase 2 NCT04177810 Nov 2020 → Mar 2023 malignant pancreatic neoplasm Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Completed No outcome recorded
Phase 2 NCT04552743 Oct 2020 → Jul 2021 plasma cell myeloma Surbhi Sidana, MD Completed Met primary
Phase 2 NCT04362293 Apr 2020 → Jun 2026 overdue sickle cell disease St. Jude Children's Research Hospital Active not recruiting No outcome recorded
Phase 36 trials · 2 met primary · 1 missed
Phase 3 NCT01767714 Apr 2013 → Nov 2014 non-Hodgkin lymphoma Sanofi Completed No outcome recorded
Phase 3 NCT01301963 Jul 2011 → Jun 2013 refractory plasma cell neoplasm Case Comprehensive Cancer Center Terminated No outcome recorded Stop: Enrollment
Phase 3 NCT01146834 Mar 2011 → Feb 2019 plasma cell myeloma Weill Medical College of Cornell University Completed Missed primary
Phase 3 NCT00838357 Sep 2008 → Nov 2010 disease related to transplantation, non-Hodgkin lymphoma Genzyme, a Sanofi Company Completed No outcome recorded
Phase 3 NCT00103662 Jan 2005 → Oct 2006 plasma cell myeloma Genzyme, a Sanofi Company Completed Met primary
Phase 3 NCT00103610 Jan 2005 → Jul 2006 non-Hodgkin lymphoma Genzyme, a Sanofi Company Completed Met primary
Phase 44 trials · 1 missed
Phase 4 NCT05510544 Dec 2022 → Dec 2023 lymphoma Peking University Unknown No outcome recorded
Phase 4 NCT05087212 Oct 2021 → Dec 2022 disease related to hematopoietic stem cell transplant Sanofi Completed No outcome recorded
Phase 4 NCT02006225 Feb 2014 → Feb 2019 disease related to hematopoietic stem cell transplant Tel-Aviv Sourasky Medical Center Unknown No outcome recorded
Phase 4 NCT01164475 Oct 2010 → Feb 2013 non-Hodgkin lymphoma Genzyme, a Sanofi Company Completed Missed primary
Phase not applicable4 trials
— NCT01408043 Oct 2011 → May 2016 Burkitt lymphoma, MALT lymphoma, T-cell large granular lymphocyte leukemia, Waldenstrom macroglobulinemia +18 Case Comprehensive Cancer Center Terminated No outcome recorded Stop: Enrollment
— NCT01076270 Jun 2010 → Jan 2011 Burkitt lymphoma, Hodgkins lymphoma, MALT lymphoma, acute myeloid leukemia with 11q23 abnormalities +19 Fred Hutchinson Cancer Center Terminated No outcome recorded Stop: Business
— NCT01186224 May 2010 → Jun 2015 lymphoproliferative syndrome, plasma cell myeloma University of Liverpool Completed No outcome recorded
— NCT01042717 Feb 2010 → Dec 2011 non-Hodgkin lymphoma, plasma cell myeloma Shi, Patricia, M.D. Unknown No outcome recorded
Comparator or background therapy34 trials
Phase 1 NCT06506461 Background Mar 2025 → Dec 2029 expected sickle cell disease St. Jude Children's Research Hospital Recruiting No outcome recorded
Phase 1 NCT04418414 Background Sep 2024 → Aug 2029 expected hemophilia A Expression Therapeutics, LLC Not yet recruiting No outcome recorded
Phase 1 NCT06414889 Background May 2024 → Jun 2027 expected hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1 M.D. Anderson Cancer Center Recruiting No outcome recorded
Phase 1 NCT05088356 Background Sep 2021 → May 2028 expected acute leukemia, chronic myeloid leukemia, disease related to hematopoietic stem cell transplant, myelodysplastic syndrome Stanford University Active not recruiting No outcome recorded
Phase 1 NCT03506802 Background Jul 2018 → Jun 2019 plasma cell myeloma Jonsson Comprehensive Cancer Center Withdrawn No outcome recorded Stop: Enrollment

News releases announcing trial results or a regulatory action · 1

DateIssuerRelease
2023-07-27 Zydus Lifesciences Limited Regulatory Zydus receives final approval from the USFDA for Plerixafor Injection USP, 24 mg/1.2 mL (20 mg/mL), Single-Dose Vial zyduslife.com ↗
Zydus Lifesciences Limited (including its subsidiaries/affiliates, hereafter referred to as “Zydus”) has received final approval from the United States Food and Drug Administration (USFDA) for Plerixafor Injection, 24 mg/1.2 mL (20 mg/mL), Single -Dose Vial (USRLD: Mozobil® Injection, 24 mg/1.2 mL [20 mg/mL]).

All press releases naming this drug 1 release

DateIssuerRelease

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 138 sources stand behind the page.

FieldValueCited text
Known as PLERIXAFOR “This study will assess the use of autologous bone marrow stem cells mobilization using 1,1'-\[1,4-phenylenebis-(methylene)\]-bis-1,4,8,11-tetraazacyclotetradecane (PLERIXAFOR)...” NCT05343572 ↗
136

“antagonists of the CXCR4 receptor (plerixafor) favors chemotaxis and HSC output to peripheral blood.” NCT02605460 ↗

“G-CSF and Plerixafor are administered by subcutaneous injection prior to apheresis.” NCT04418414 ↗

“Day 0: Plerixafor 240 mcg/kg subcutaneous 9-12 hours prior to transplant” NCT01182675 ↗

“Patients will receive G-CSF (Filgrastim) plus Mozobil (Plerixafor)” NCT01711073 ↗

“* Venetoclax * Plerixafor GVHD prophylaxis” NCT04000698 ↗

“Plerixafor” NCT02750254 ↗

NCT05343572 ↗

NCT03182426 ↗

NCT01331018 ↗

NCT01352650 ↗

Show 126 more sources

Known as AMD3100 “PURPOSE: This study evaluates the safety and efficacy of plerixafor (AMD3100), a CXCR4 antagonist, in mobilizing hematopoietic stem cells for autologous stem-cell...” PMID 19720922 ↗ Aug 2009
6

“Plerixafor (previously known as AMD3100), a selective antagonist of CXCR4, has recently been approved for autologous HSC mobilization in combination with G-CSF.” PMID 20067838 ↗ Jan 2010

“Evaluation of Plerixafor (Mozobil ™, AMD3100) in Combination With Chemotherapy and G-CSF for CD34+ Cell Mobilization” NCT01095757 ↗

“Drug: AMD3100 or plerixafor” NCT01058993 ↗

“plerixafor (AMD 3100)” NCT01186224 ↗

“Plerixafor (AMD3100)” NCT00665314 ↗

“AMD3100” NCT00322842 ↗

Known as GZ316455 “plerixafor GZ316455” NCT02221479 ↗
1

“plerixafor GZ316455” NCT02221492 ↗

Known as mozobil “Trial of an Augmented Mobilization Strategy With Plerixafor (Mozobil®) in a Population at Risk for Poor Stem Cell Mobilization” NCT01037517 ↗
7

“Plerixafor (Mozobil) alone to mobilize hematopoietic stem cells from multiple myeloma patients for autologous transplantation.” PMID 20067838 ↗ Jan 2010

“Evaluation of Plerixafor (Mozobil ™, AMD3100) in Combination With Chemotherapy and G-CSF for CD34+ Cell Mobilization” NCT01095757 ↗

“Plerixafor (mozobil) 240 mcg/kg SC will be administered in the evening, 10 hours prior to initiation of apheresis.” NCT01164345 ↗

“Plerixafor (Mozobil®) continuous intravenous infusion for 7 days” NCT05411575 ↗

“plerixafor (Mozobil®)” NCT00990054 ↗

“Plerixafor (mozobil)” NCT06872333 ↗

“Plerixafor, mozobil” NCT01225419 ↗

Action Inhibit “This study evaluates the safety and efficacy of plerixafor (AMD3100), a CXCR4 antagonist, in mobilizing hematopoietic stem cells for autologous stem-cell transplantation in...” PMID 19720922 ↗ Aug 2009
Modality Small molecule “bicyclam small molecule inhibitor” NCT01065129 ↗
Route Subcutaneous “patients received either plerixafor (240 microg/kg) or placebo subcutaneously” PMID 19720922 ↗ Aug 2009
Target CXCR4 “This study evaluates the safety and efficacy of plerixafor (AMD3100), a CXCR4 antagonist, in mobilizing hematopoietic stem cells for autologous stem-cell transplantation in...” PMID 19720922 ↗ Aug 2009