Alternative Sedation During Bronchoscopy

Phase 4 Completed 50 enrolled University of Pennsylvania Hospira, now a wholly owned subsidiary of Pfizer · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

This protocol hopes to determine whether the use of dexmedetomidine-ketamine can reduce the use of standard of care fentanyl-midazolam sedation during bronchoscopy. This may result in less respiratory depression while providing better compliance with the procedure.

Timeline

Start: 2010-06
Primary completion: 2012-05
Completion: 2012-05

Publications

Results Yarmus LB, Akulian JA, Gilbert C, Mathai SC, Sathiyamoorthy S, Sahetya S, Harris K, Gillespie C, Haas A, Feller-Kopman D, Sterman D, Lee HJ. Comparison of moderate versus deep sedation for endobronchial ultrasound transbronchial needle aspiration. Ann Am Thorac Soc. 2013 Apr;10(2):121-6. doi: 10.1513/AnnalsATS.201209-074OC.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Dexmedetomidine	Other / unclassified	0.5 ug/kg	—
Comparator	Fentanyl	Other / unclassified	12.5 ug	—
Comparator	Ketamine	Small molecule	8 ug/kg	—
Comparator	Midazolam	Small molecule	0.5 mg	—
Comparator	Diphenhydramine	Unknown	25 mg	—

Indications

No indication recorded.