Assessment of Systemic Pharmacokinetics of Levobupivacaine and Ropivacaine During Continuous Epidural Infusion

Summary

The aim of the study is the assessment of the systemic absorption of local anesthetics during continuous epidural infusion for postoperative pain control.

Timeline

Start

2005-07

Primary completion

2011-06

Completion

2011-07

Outcome

Met primary endpoint

paper The comparison between the 2 CVs showed no statistical difference: the difference between area under the curve was within the range of 15%. PMID 25977992 ↗

paper Considering the CV, the interindividual variability of plasma concentration for levobupivacaine and ropivacaine is equivalent after thoracic epidural infusion in adults. PMID 25977992 ↗

Publications

• Perotti L, Cusato M, Ingelmo P, Niebel TL, Somaini M, Riva F, Tinelli C, De Andres J, Fanelli G, Braschi A, Regazzi M, Allegri M. A Comparison of Differences Between the Systemic Pharmacokinetics of Levobupivacaine and Ropivacaine During Continuous Epidural Infusion: A Prospective, Randomized, Multicenter, Double-Blind Controlled Trial. Anesth Analg. 2015 Aug;121(2):348-56. doi: 10.1213/ANE.0000000000000775.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Levobupivacaine	Other / unclassified	0.125 %	Other
Subject	Ropivacaine	Other / unclassified	0.2 %	Other
Background	Sufentanil	Other / unclassified	0.75 ug/ml	Other

Indications

No indication recorded.