Assessment of Systemic Pharmacokinetics of Levobupivacaine and Ropivacaine During Continuous Epidural Infusion

Phase 4 Completed 181 enrolled Fondazione IRCCS Policlinico San Matteo di Pavia

RandomizedParallel-groupTriple-blindTreatment

Summary

The aim of the study is the assessment of the systemic absorption of local anesthetics during continuous epidural infusion for postoperative pain control.

Timeline

Start: 2005-07
Primary completion: 2011-06
Completion: 2011-07

Publications

Perotti L, Cusato M, Ingelmo P, Niebel TL, Somaini M, Riva F, Tinelli C, De Andres J, Fanelli G, Braschi A, Regazzi M, Allegri M. A Comparison of Differences Between the Systemic Pharmacokinetics of Levobupivacaine and Ropivacaine During Continuous Epidural Infusion: A Prospective, Randomized, Multicenter, Double-Blind Controlled Trial. Anesth Analg. 2015 Aug;121(2):348-56. doi: 10.1213/ANE.0000000000000775.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Levobupivacaine	Other / unclassified	0.125 %	Other
Subject	Ropivacaine	Other / unclassified	0.2 %	Other
Background	Sufentanil	Other / unclassified	0.75 ug/ml	Other

Indications

No indication recorded.