Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men

Phase 2 Completed 51 enrolled National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

RandomizedCrossoverTriple-blindTreatment

Summary

This study proposes to examine multiple aspects of the hypothalamic-pituitary-adrenal axis in younger endurance trained and sedentary men, and in older sedentary men.

Timeline

Start: 2011-01-24
Primary completion: 2016-08-10
Completion: 2016-08-10

Outcome

Missed primary endpoint

registry analysis (superiority test); Endurance-trained Young Athletes vs Sedentary Young Adults; p = 0.4872; Fisher Exact NCT01294319 ↗

Publications

Background Bauer ME. Stress, glucocorticoids and ageing of the immune system. Stress. 2005 Mar;8(1):69-83. doi: 10.1080/10253890500100240.
Background Bertagna X, Bertagna C, Luton JP, Husson JM, Girard F. The new steroid analog RU 486 inhibits glucocorticoid action in man. J Clin Endocrinol Metab. 1984 Jul;59(1):25-8. doi: 10.1210/jcem-59-1-25.
Background Booth CK, Probert B, Forbes-Ewan C, Coad RA. Australian army recruits in training display symptoms of overtraining. Mil Med. 2006 Nov;171(11):1059-64. doi: 10.7205/milmed.171.11.1059.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexamethasone	Small molecule	0.25 mg	—
Subject	Mifepristone	Small molecule	400 mg	—
Subject	Spironolactone	Small molecule	200 mg	—