drugset / Trial / NCT01294319
Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men
Phase 2
Completed
51 enrolled
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
RandomizedCrossoverTriple-blindTreatment
Summary
This study proposes to examine multiple aspects of the hypothalamic-pituitary-adrenal axis in younger endurance trained and sedentary men, and in older sedentary men.
Timeline
- Start
- 2011-01-24
- Primary completion
- 2016-08-10
- Completion
- 2016-08-10
Publications
- Background Bauer ME. Stress, glucocorticoids and ageing of the immune system. Stress. 2005 Mar;8(1):69-83. doi: 10.1080/10253890500100240.
- Background Bertagna X, Bertagna C, Luton JP, Husson JM, Girard F. The new steroid analog RU 486 inhibits glucocorticoid action in man. J Clin Endocrinol Metab. 1984 Jul;59(1):25-8. doi: 10.1210/jcem-59-1-25.
- Background Booth CK, Probert B, Forbes-Ewan C, Coad RA. Australian army recruits in training display symptoms of overtraining. Mil Med. 2006 Nov;171(11):1059-64. doi: 10.7205/milmed.171.11.1059.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexamethasone | Small molecule | 0.25 mg | — |
| Subject | Mifepristone | Small molecule | 400 mg | — |
| Subject | Spironolactone | Small molecule | 200 mg | — |