The Median Effective Dose (ED50) of Paracetamol and Morphine : A Study of Interaction Study

Completed 90 enrolled Procare Riaya Hospital

RandomizedParallel-groupDouble-blindTreatment

Summary

The aim of our study is to define the median effective analgesic doses (ED50) of paracetamol, morphine, and their combination and determination the nature of their interaction administered IV for postoperative pain after moderate painful surgery using up-and-down and isobolographic methods.

Timeline

Start: 2007-09
Primary completion: 2011-03
Completion: 2011-03

Publications

Zeidan A, Mazoit JX, Ali Abdullah M, Maaliki H, Ghattas T, Saifan A. Median effective dose (ED(5)(0)) of paracetamol and morphine for postoperative pain: a study of interaction. Br J Anaesth. 2014 Jan;112(1):118-23. doi: 10.1093/bja/aet306. Epub 2013 Oct 24.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Acetaminophen	Small molecule	1.5 g	Intravenous
Subject	Acetaminophen	Small molecule	2.5 g	Intravenous
Subject	Morphine	Other / unclassified	3 mg	Intravenous
Subject	Morphine	Other / unclassified	5 mg	Intravenous

Indications

No indication recorded.