Pharmacokinetic Study to Characterize Phenotyping Metrics of the "Basel" Cocktail After CYP Induction or Inhibition

Phase 1 Completed 16 enrolled University Hospital, Basel, Switzerland

RandomizedCrossoverOpen-label

Summary

The purpose of this study is to assess how the pharmacokinetic profiles of each drug of a cocktail of six approved drugs (so-called "Basel cocktail") change when the cytochrome P450 system is inhibited or induced.

Timeline

Start: 2011-05
Primary completion: 2012-01
Completion: 2012-01

Publications

Derungs A, Donzelli M, Berger B, Noppen C, Krahenbuhl S, Haschke M. Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study. Clin Pharmacokinet. 2016 Jan;55(1):79-91. doi: 10.1007/s40262-015-0294-y.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Caffeine	Small molecule	—	—
Subject	Ciprofloxacin	Small molecule	—	—
Subject	Efavirenz	Other / unclassified	—	—
Subject	Fluconazole	Small molecule	—	—
Subject	Losartan	Other / unclassified	—	—
Subject	Metoprolol	Other / unclassified	—	—
Subject	Midazolam	Small molecule	—	—
Subject	Omeprazole	Other / unclassified	—	—
Subject	Paroxetine	Small molecule	—	—
Subject	Rifampin	Small molecule	—	—

Indications

No indication recorded.