drugset / Trial / NCT01537107

Sirolimus and Vismodegib in Treating Patients With Solid Tumors or Pancreatic Cancer That is Metastatic or Cannot Be Removed By Surgery

NCT01537107

Phase 1 Completed 31 enrolled Mayo Clinic
NaSingle-groupOpen-labelTreatment

Summary

This phase I trial studies the side effects and the best dose of sirolimus when given together with vismodegib in treating patients with solid tumors or pancreatic cancer that is metastatic or cannot be removed by surgery. Sirolimus and vismodegib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth

Timeline

Start
2012-03-05
Primary completion
2018-06-27
Completion
2018-06-27

Drugs

EvaluationDrugModalityDoseRoute
Subject Sirolimus Small molecule Oral
Subject Vismodegib Small molecule Oral