Phase 0 5 trials · 2 met primary
Phase 0
NCT05651828 Mar 2023 → Dec 2028 expected basal cell carcinoma H. Lee Moffitt Cancer Center and Research Institute
Recruiting
No outcome recorded
Phase 0
NCT05238831 Jan 2023 → May 2026 female breast carcinoma , ovarian carcinoma , pancreatic ductal adenocarcinoma , pancreatic large cell neuroendocrine carcinoma +2 OHSU Knight Cancer Institute
Withdrawn
No outcome recorded
Phase 0
NCT02115828 Apr 2014 → Apr 2016 prostate cancer Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Completed
Met primary
Phase 0
NCT01713218 Dec 2012 → Jun 2014 pancreatic adenocarcinoma Jean-Luc Van Laethem
Unknown
No outcome recorded
Phase 0
NCT01631331 Jun 2012 → Sep 2015 skin basal cell carcinoma Stanford University
Completed
Met primary
Phase 1 17 trials
Phase 1
NCT06616623 Dec 2024 → Dec 2026 non-small cell lung carcinoma Dwight Owen
Suspended
No outcome recorded
Phase 1
NCT03878524 Apr → Dec 2020 acute myeloid leukemia , atypical chronic myeloid leukemia, BCR-ABL1 negative , blast phase chronic myelogenous leukemia, BCR-ABL1 positive , castration-resistant prostate carcinoma +14 OHSU Knight Cancer Institute
Terminated
No outcome recorded
Stop: Enrollment
Phase 1
NCT02593760 Jan 2016 → Mar 2017 myelofibrosis Hoffmann-La Roche
Completed
No outcome recorded
Phase 1
NCT02648048 Jan → Nov 2016 idiopathic pulmonary fibrosis Hoffmann-La Roche
Completed
No outcome recorded
Phase 1
NCT02639117 Nov 2015 → Nov 2016 basal cell carcinoma University of Arizona
Completed
No outcome recorded
Phase 1
NCT01772290 Feb → May 2013 —
Genentech, Inc.
Completed
No outcome recorded
Phase 1
NCT01537107 Mar 2012 → Jun 2018 pancreatic acinar cell carcinoma , pancreatic ductal adenocarcinoma Mayo Clinic
Completed
No outcome recorded
Phase 1
NCT01546519 Mar 2012 → Apr 2014 cancer Genentech, Inc.
Completed
No outcome recorded
Phase 1
NCT01330173 Dec 2010 → Oct 2014 plasma cell myeloma National Cancer Institute (NCI)
Completed
No outcome recorded
Phase 1
NCT01209143 Nov 2010 → Mar 2012 —
Genentech, Inc.
Completed
No outcome recorded
Phase 1
NCT01173536 Aug 2010 → Mar 2011 —
Genentech, Inc.
Completed
No outcome recorded
Phase 1
NCT01071564 Nov 2009 → Jun 2014 triple-negative breast carcinoma National Cancer Institute (NCI)
Terminated
No outcome recorded
Phase 1
NCT00991718 Sep 2009 → Aug 2010 —
Genentech, Inc.
Completed
No outcome recorded
Phase 1
NCT00968981 Sep 2009 → Oct 2010 —
Genentech, Inc.
Completed
No outcome recorded
Phase 1
NCT00878163 Mar 2009 → Jan 2013 overdue pancreatic acinar cell carcinoma , pancreatic ductal adenocarcinoma National Cancer Institute (NCI)
Active not recruiting
No outcome recorded
Phase 1
NCT00822458 Jan 2009 → Sep 2013 childhood medulloblastoma National Cancer Institute (NCI)
Completed
No outcome recorded
Phase 1
NCT00607724 Apr 2007 → Nov 2009 cancer of unknown primary site Genentech, Inc.
Completed
No outcome recorded
Show 7 more trials Phase 1/2 5 trials
Phase 1/2
NCT02690948 Feb 2016 → Nov 2017 skin basal cell carcinoma Anne Chang
Completed
No outcome recorded
Phase 1/2
NCT01601184 Jun 2012 → Sep 2017 medulloblastoma SHH activated Centre Leon Berard
Terminated
No outcome recorded
Phase 1/2
NCT01163084 Jul 2010 → Jun 2012 prostate adenocarcinoma National Cancer Institute (NCI)
Terminated
No outcome recorded
Phase 1/2
NCT01154452 Jun 2010 → Feb 2015 Ewing sarcoma/peripheral primitive neuroectodermal tumor , Kaposi's sarcoma , adult epithelioid sarcoma , adult extraskeletal osteosarcoma +18 National Cancer Institute (NCI)
Completed
No outcome recorded
Phase 1/2
NCT01174264 Oct 2009 → Dec 2014 cancer National Cancer Institute (NCI)
Completed
Mixed
Phase 2 49 trials · 4 met primary · 6 missed
Phase 2
NCT07802418 Oct 2026 → Jun 2031 expected malignant pancreatic neoplasm Herlev Hospital
Not yet recruiting
No outcome recorded
Phase 2
NCT05538091 May 2023 → Aug 2031 expected fallopian tube carcinoma , primary peritoneal carcinoma Ronald Buckanovich
Recruiting
No outcome recorded
Phase 2
NCT05159245 Dec 2021 → Nov 2026 expected cancer , hematopoietic and lymphoid cell neoplasm Helsinki University Central Hospital
Recruiting
No outcome recorded
Phase 2
NCT04817956 Apr 2021 → Mar 2040 expected metastatic malignant neoplasm Oslo University Hospital
Recruiting
No outcome recorded
Phase 2
NCT04341181 Aug 2020 → Apr 2029 expected cancer Ulrik Lassen
Recruiting
No outcome recorded
Phase 2
NCT03767439 Jul → Dec 2019 nevoid basal cell carcinoma syndrome Columbia University
Withdrawn
No outcome recorded
Stop: Business
Phase 2
NCT03498521 Jul 2018 → Feb 2023 cancer of unknown primary site Hoffmann-La Roche
Completed
Met primary
Phase 2
NCT03297606 Mar 2018 → Dec 2026 expected non-Hodgkin lymphoma , plasma cell myeloma Canadian Cancer Trials Group
Recruiting
No outcome recorded
Phase 2
NCT02788201 Mar 2017 → Oct 2019 urinary bladder cancer , urothelial carcinoma National Cancer Institute (NCI)
Completed
No outcome recorded
Phase 2
NCT03052478 Feb 2017 → Dec 2019 gastric neoplasm Samsung Medical Center
Completed
No outcome recorded
Phase 2
NCT03035188 Jan 2017 → Jan 2020 basal cell carcinoma SRH Wald-Klinikum Gera GmbH
Completed
No outcome recorded
Phase 2
NCT02956889 Oct 2016 → Feb 2019 basal cell carcinoma Istituto Clinico Humanitas
Terminated
No outcome recorded
Stop: Enrollment
Phase 2
NCT02925234 Aug 2016 → Sep 2027 expected cancer The Netherlands Cancer Institute
Recruiting
Mixed
Phase 2
NCT06357988 Jun 2016 → Nov 2022 overdue adult lymphoma , plasma cell myeloma , refractory malignant neoplasm National Cancer Institute (NCI)
Active not recruiting
No outcome recorded
Phase 2
NCT02694224 Apr 2016 → Dec 2017 breast cancer Clinica Universidad de Navarra, Universidad de Navarra
Unknown
No outcome recorded
Phase 2
NCT02366312 Oct 2015 → Aug 2019 Keratocystic odontogenic tumor NYU College of Dentistry
Completed
No outcome recorded
Phase 2
NCT02523014 Sep 2015 → Jan 2027 expected NF2-related schwannomatosis , intracranial meningioma Alliance for Clinical Trials in Oncology
Recruiting
Met primary
Phase 2
NCT02337517 Sep 2015 → Jun 2018 chronic graft versus host disease National Cancer Institute (NCI)
Terminated
No outcome recorded
Phase 2
NCT02465060 Aug 2015 → Dec 2027 expected breast carcinoma , carcinoma of esophagus , cervical carcinoma , colon carcinoma +17 National Cancer Institute (NCI)
Active not recruiting
No outcome recorded
Phase 2
NCT02073838 May 2015 → Nov 2022 acute myeloid leukemia Sarit Assouline
Completed
No outcome recorded
Phase 2
NCT02667574 Nov 2014 → Jul 2020 basal cell carcinoma University Hospital, Lille
Completed
No outcome recorded
Phase 2
NCT02168530 Oct 2014 → Jan 2017 idiopathic pulmonary fibrosis Hoffmann-La Roche
Withdrawn
No outcome recorded
Phase 2
NCT02091141 Apr 2014 → May 2023 biliary tract cancer , salivary gland cancer , urinary bladder cancer Genentech, Inc.
Completed
No outcome recorded
Phase 2
NCT02067104 Feb 2014 → Dec 2016 basal cell carcinoma University of Arizona
Terminated
No outcome recorded
Stop: Enrollment
Phase 2
NCT01898598 Jan 2014 → Jan 2016 basal cell carcinoma Hoffmann-La Roche
Terminated
No outcome recorded
Phase 2
NCT01880437 Sep 2013 → Nov 2014 myelodysplastic syndrome Hoffmann-La Roche
Terminated
No outcome recorded
Phase 2
NCT01878617 Jun 2013 → Oct 2028 expected childhood medulloblastoma St. Jude Children's Research Hospital
Active not recruiting
No outcome recorded
Phase 2
NCT01835626 May 2013 → Sep 2019 skin basal cell carcinoma Sue Yom
Completed
No outcome recorded
Phase 2
NCT01774253 May 2013 → Oct 2015 brain stem glioma Giselle Sholler
Terminated
No outcome recorded
Stop: Enrollment
Phase 2
NCT01815840 Apr 2013 → Aug 2015 basal cell carcinoma Hoffmann-La Roche
Completed
Missed primary
Phase 2
NCT01944943 Feb 2013 → Aug 2014 chronic lymphocytic leukemia/small lymphocytic lymphoma , diffuse large B-cell lymphoma , primary central nervous system lymphoma The Lymphoma Academic Research Organisation
Terminated
No outcome recorded
Phase 2
NCT01700049 Jan 2013 → Jul 2017 basal cell carcinoma Mayo Clinic
Completed
No outcome recorded
Phase 2
NCT01367665 Jul 2011 → Jun 2017 basal cell carcinoma Hoffmann-La Roche
Completed
No outcome recorded
Phase 2
NCT01096732 Feb 2011 → Aug 2012 pancreatic ductal adenocarcinoma Lisa Bax
Terminated
No outcome recorded
Stop: Enrollment
Phase 2
NCT01267955 Dec 2010 → Jun 2018 overdue clear cell chondrosarcoma , dedifferentiated chondrosarcoma , mesenchymal chondrosarcoma National Cancer Institute (NCI)
Active not recruiting
Missed primary
Phase 2
NCT01239316 Nov 2010 → Jun 2014 childhood medulloblastoma National Cancer Institute (NCI)
Completed
No outcome recorded
Phase 2
NCT01201915 Oct 2010 → May 2013 basal cell carcinoma Genentech, Inc.
Completed
No outcome recorded
Phase 2
NCT01088815 Sep 2010 → Dec 2017 pancreatic ductal adenocarcinoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Completed
Missed primary
Phase 2
NCT01195415 Jun 2010 → Jul 2013 digestive system carcinoma , pancreas disorder National Cancer Institute (NCI)
Completed
No outcome recorded
Phase 2
NCT00980343 Feb 2010 → May 2012 adult glioblastoma , giant cell glioblastoma , gliosarcoma National Cancer Institute (NCI)
Completed
No outcome recorded
Phase 2
NCT00959647 Sep 2009 → Jan 2014 basal cell carcinoma , colorectal cancer , ovarian cancer Genentech, Inc.
Completed
No outcome recorded
Phase 2
NCT01064622 Sep 2009 → Dec 2012 pancreatic adenocarcinoma National Cancer Institute (NCI)
Completed
Missed primary
Phase 2
NCT00982592 Sep 2009 → Apr 2012 gastric adenocarcinoma , gastroesophageal junction adenocarcinoma National Cancer Institute (NCI)
Completed
Missed primary
Phase 2
NCT00957229 Aug 2009 → Jan 2014 nevoid basal cell carcinoma syndrome UCSF Benioff Children's Hospital Oakland
Completed
Met primary
Phase 2
NCT00887159 Jul 2009 → Nov 2016 small cell lung carcinoma National Cancer Institute (NCI)
Completed
Missed primary
Phase 2
NCT00939484 Jun 2009 → May 2013 adult medulloblastoma National Cancer Institute (NCI)
Completed
No outcome recorded
Phase 2
NCT00833417 Feb 2009 → Nov 2010 basal cell carcinoma Genentech, Inc.
Completed
Met primary
Phase 2
NCT00739661 Dec 2008 → Nov 2010 ovarian cancer Genentech, Inc.
Completed
No outcome recorded
Phase 2
NCT00636610 May 2008 → Dec 2010 colorectal cancer Genentech, Inc.
Completed
No outcome recorded
Show 39 more trials Phase 4 2 trials · 1 met primary
Phase 4
NCT03610022 Sep 2018 → May 2021 skin basal cell carcinoma University Hospital, Bordeaux
Completed
No outcome recorded
Phase 4
NCT02436408 Jul 2015 → Sep 2020 basal cell carcinoma University of Michigan Rogel Cancer Center
Completed
Met primary
Phase not stated 1 trial
— NCT01160250 Jul 2010 → Apr 2012 basal cell carcinoma Genentech, Inc.
Approved for marketing
No outcome recorded
Comparator or background therapy 5 trials
Phase 1/2
NCT03158389 Background May 2018 → Feb 2023 adult glioblastoma University Hospital Heidelberg
Completed
Mixed
Phase 2
NCT06344052 Background Apr 2024 → Sep 2026 overdue basal cell carcinoma Stamford Pharmaceuticals, Inc.
Recruiting
No outcome recorded
Phase 2
NCT05561634 Background Jun 2023 → Jun 2029 expected basal cell carcinoma University Hospital, Lille
Recruiting
No outcome recorded
Phase 2
NCT01543581 Comparator May 2012 → Jun 2013 basal cell carcinoma Abel Torres, MD
Completed
No outcome recorded
Phase 2
NCT01556009 Comparator Apr 2012 → Dec 2015 nevoid basal cell carcinoma syndrome UCSF Benioff Children's Hospital Oakland
Completed
No outcome recorded