drugset / Trial / NCT01637194
Cetuximab and Everolimus in Treating Patients With Metastatic or Recurrent Colon Cancer or Head and Neck Cancer
NaSingle-groupOpen-labelTreatment
Summary
This phase I trial studies the side effects and best dose of cetuximab when given together with everolimus in treating patients with metastatic or recurrent colon cancer or head and neck cancer. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of the tumor to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Everolimus may stop the growth of tumor cells by blocking blood flow to the tumor. Giving cetuximab together with everolimus may be an effective treatment for colon cancer or head and neck cancer
Timeline
- Start
- 2008-11
- Primary completion
- 2011-07
- Completion
- 2011-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cetuximab | Monoclonal antibody | — | Intravenous |
| Subject | Everolimus | Small molecule | — | Oral |
Indications
adenoid cystic carcinoma
carcinoma of lip
colorectal cancer
esthesioneuroblastoma
hypopharynx squamous cell carcinoma
inverted papilloma
larynx verrucous carcinoma
lymphoepithelial-like carcinoma
metastatic squamous cell carcinoma
nasal cavity and paranasal sinus lethal midline granuloma
nasal cavity and paranasal sinus squamous cell carcinoma
nasopharyngeal squamous cell carcinoma
oral cavity mucoepidermoid carcinoma
oropharynx squamous cell carcinoma
salivary gland cancer
tongue cancer
undifferentiated carcinoma of nasopharynx
verrucous carcinoma of oral cavity