drugset / Trial / NCT01638988

Clomifene Citrate Versus Metformin in First-line Treatment of Infertility in Patients With Polycystic Ovary Syndrome and a Resistance to Insulin

NCT01638988

Phase 3 Withdrawn Clinique Ovo
RandomizedParallel-groupOpen-labelTreatment

Summary

The results of studies conducted until now does not determine what the best way to treat infertility in the first line with patients with Polycystic ovary syndrome (PCOS). This study objective is to determine the best treatment for such patients. The long-term consequence health of women with PCOS are multiple. The woman with PCOS has a risk of developing metabolic diseases, heart diseases, diabetes Type II or anovulatory infertility. The insulin resistance plays an important role in all this medical condition. Clomiphene Citrate (CC) remains the first line treatment to induce ovulation in women with PCOS and anovulatory infertility.

Timeline

Start
2013-09
Primary completion
2013-11
Completion
2015-12

Drugs

EvaluationDrugModalityDoseRoute
Comparator Clomiphene Other / unclassified 150 mg
Subject Metformin Small molecule 2000 mg