drugset / Trial / NCT01707329

Icotinib in Combination With Chemotherapy Versus Chemotherapy Alone in Patients Progressed After Icotinib Treatment

NCT01707329

Phase 2 Unknown 180 enrolled Betta Pharmaceuticals Co., Ltd.
RandomizedParallel-groupOpen-labelTreatment

Summary

This phase II randomised, double blind, placebo controlled, multicentre trial is designed to assess the efficacy and safety of continuous icotinib plus chemotherapy versus chemotherapy alone in patients who have progressed after benefiting from previous second or third-line icotinib treatment (more than 6 months) in locally advanced or metastatic non-small cell lung cancer.

Timeline

Start
2012-09
Primary completion
2016-07
Completion
2016-12

Drugs

EvaluationDrugModalityDoseRoute
Subject Docetaxel Small molecule 60 mg/m2
Subject Docetaxel Small molecule 75 mg/m2
Subject Icotinib Small molecule 125 mg Oral
Background Pemetrexed Small molecule 500 mg/m2