Xenon in Off-pump Coronary Artery Bypass Graft Surgery

Phase 2 Completed 42 enrolled Universitaire Ziekenhuizen KU Leuven

RandomizedParallel-groupDouble-blindTreatment

Summary

Purpose of this study is to test whether xenon application during off-pump-coronary artery bypass (OPCAB)-surgery is safe and feasible.

Timeline

Start: 2012-12
Primary completion: 2013-07
Completion: 2014-01

Outcome

Met primary endpoint

paper Xenon was non-inferior to sevoflurane, as xenon patients required significantly less noradrenaline intraoperatively to achieve the predefined haemodynamic goals PMID 26385664 ↗

paper {geometric mean 428 [95% confidence interval (CI) 312, 588] vs 1702 [1267, 2285] µg, P<0.0001} PMID 26385664 ↗

Publications

Al Tmimi L, Van Hemelrijck J, Van de Velde M, Sergeant P, Meyns B, Missant C, Jochmans I, Poesen K, Coburn M, Rex S. Xenon anaesthesia for patients undergoing off-pump coronary artery bypass graft surgery: a prospective randomized controlled pilot trial. Br J Anaesth. 2015 Oct;115(4):550-9. doi: 10.1093/bja/aev303.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Sevoflurane	Other / unclassified	1.4 %	Inhaled
Subject	Xenon	Other / unclassified	50 %	Inhaled
Subject	Xenon	Other / unclassified	60 %	Inhaled