drugset / Trial / NCT01762787
Phase I Methodology Study to Validate the Cantharidin Blister Model in Healthy Volunteers
RandomizedCrossoverSingle-blindOther
Summary
The purpose of this study is to refine the cantharidin-induced blister assay in healthy volunteers as a model of inflammatory disease. The study is an experimental trial in healthy volunteers in two parts; Part 1 to optimise the model and Part 2 to validate using two anti-inflammatory treatments with different modes of action.
Timeline
- Start
- 2010-08-17
- Primary completion
- 2011-01-14
- Completion
- 2011-01-14
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Aspirin | Small molecule | 300 mg | Oral |
| Subject | Cantharidin | Small molecule | 0.005 ml | Topical |
| Subject | Cantharidin | Small molecule | 0.025 % | Topical |
| Subject | Cantharidin | Small molecule | 0.5 % | Topical |
| Subject | Prednisolone | Other / unclassified | 30 mg | Oral |
Indications
No indication recorded.