drugset / Trial / NCT01768663
A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects
Non-randomizedSingle-groupOpen-labelTreatment
Summary
The purpose of this study is to examine the drug-drug interaction effects of ciprofloxacin, itraconazole, and rifampin on the pharmacokinetics of lumacaftor in combination with ivacaftor as well as to evaluate the potential effects of lumacaftor in combination with ivacaftor on lung function.
Timeline
- Start
- 2013-01
- Primary completion
- 2013-09
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ciprofloxacin | Small molecule | 750 mg | — |
| Subject | Itraconazole | Small molecule | 200 mg | — |
| Subject | Ivacaftor | Other / unclassified | 250 mg | — |
| Subject | Lumacaftor | Small molecule | 200 mg | — |
| Subject | Rifampicin | Small molecule | 600 mg | — |