drugset / Trial / NCT01790282
Is Adding E2 to P4 Luteal Support In High Responder Long Gn-RH Agonist ICSI Cycles Detrimental to Outcome? RCT
RandomizedParallel-groupOpen-labelTreatment
Summary
Study if supporting luteal phase of high responder (high egg production or high Estradiol level) long Gn\_Rh agonist protocol ICSI/IVF cycle by combined Estradiol and progesterone impairs or improves outcome in terms of pregnancy and implanation rates.
Timeline
- Start
- 2013-03
- Primary completion
- 2014-12
- Completion
- 2015-03
Publications
- Background Gelbaya TA, Kyrgiou M, Tsoumpou I, Nardo LG. The use of estradiol for luteal phase support in in vitro fertilization/intracytoplasmic sperm injection cycles: a systematic review and meta-analysis. Fertil Steril. 2008 Dec;90(6):2116-25. doi: 10.1016/j.fertnstert.2007.10.053. Epub 2008 Jan 7.
- Background Sunkara SK, Rittenberg V, Raine-Fenning N, Bhattacharya S, Zamora J, Coomarasamy A. Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles. Hum Reprod. 2011 Jul;26(7):1768-74. doi: 10.1093/humrep/der106. Epub 2011 May 10.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Estradiol | Other / unclassified | 2 mg | — |
| Background | Decapeptyl | Unknown | 0.1 mg | Intramuscular |
| Background | Progesterone | Other / unclassified | 100 mg | — |
| Background | treptorline | Unknown | 0.1 mg | Subcutaneous |