drugset / Trial / NCT01822405
Treatment of Radiation-induced Fibrosis in the Upper Aerodigestive Tract Cancer by a Combination of Pentoxifylline-tocopherol and Hyperbaric Oxygen
Phase 2
Unknown
42 enrolled
Hospital Universitario de Canarias
Instituto Médico Tinerfeño IMETISA · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The pentoxifylline used with tocopherol achieves a certain effectiveness in the treatment of the fibrosis. Hyperbaric oxygen therapy has been recommended and used in a wide variety of medical conditions including the treatment of delayed radiation injuries (soft tissue and bony radiation necrosis). The hyperbaric oxygen therapy increases the formation of granulation tissue and produces angiogenesis maintained after use.
Timeline
- Start
- 2010-07
- Primary completion
- 2013-07
- Completion
- 2013-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Pentoxifylline | Small molecule | 800 mg | Oral |
| Comparator | Vitamin E | Other / unclassified | 1000 mg | Oral |
Indications
No indication recorded.