drugset / Trial / NCT01837446
Morphine Mouthwash for Management of Oral Mucositis in Patients With Head and Neck Cancer
RandomizedParallel-groupTriple-blindTreatment
Summary
Oral mucositis is a debilitating side effects of cancer treatment for which there is not much successful treatments at yet. The investigators are going to evaluate the effectiveness of topical morphine compared with a routine mouthwash in managing cancer treatment-induced mucositis. The investigators hypothesize that topical morphine is more effective and more satisfied by patients than the magic mouthwash in reducing severity of cancer treatment-induced oral mucositis.
Timeline
- Start
- 2011-07
- Primary completion
- 2012-07
- Completion
- 2012-10
Publications
- Background Cerchietti LC, Navigante AH, Bonomi MR, Zaderajko MA, Menendez PR, Pogany CE, Roth BM. Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma. Cancer. 2002 Nov 15;95(10):2230-6. doi: 10.1002/cncr.10938.
- Background Cerchietti L. Morphine mouthwashes for painful mucositis. Support Care Cancer. 2007 Jan;15(1):115-6; author reply 117. doi: 10.1007/s00520-006-0124-8. Epub 2006 Aug 15. No abstract available.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Morphine | Other / unclassified | 20 mg | Topical |
| Comparator | Diphenhydramine | Unknown | 60 ml | Topical |
| Comparator | Lidocaine | Other / unclassified | 2 % | Topical |
| Comparator | Lidocaine | Other / unclassified | 25 ml | Topical |
| Comparator | Magnesium aluminum hydroxide | Unknown | 240 ml | Topical |