A Phase II Trial of Combined Hydroxychloroquine and Sirolimus in Soft Tissue Sarcoma

Summary

Determine the objective response rate in sarcoma patients treated with hydroxychloroquine and sirolimus.

Timeline

Start

2012-08

Primary completion

2015-01

Completion

2015-01

Outcome

Outcome not reported

Stopped: “Most patients completed only the primary objective (PET) and not went throught the secondary outcome (efficacy phase) of 8wks period.”

Publications

• Chi MS, Lee CY, Huang SC, Yang KL, Ko HL, Chen YK, Chung CH, Liao KW, Chi KH. Double autophagy modulators reduce 2-deoxyglucose uptake in sarcoma patients. Oncotarget. 2015 Oct 6;6(30):29808-17. doi: 10.18632/oncotarget.5060.

Drugs

Indications