drugset / Trial / NCT01876966
Interaction Between Etravirine or Darunavir/Ritonavir and Artemether / Lumefantrine
RandomizedCrossoverOpen-labelHealth-services research
Summary
The purpose of this study is to investigate the pharmacokinetic interaction between etravirine and artemether/lumefantrine and darunavir/ritonavir and artemether/lumefantrine in healthy Human Immunodeficiency Virus- (HIV-)negative patients. 'Pharmacokinetic interaction' means that one medication can influence the absorption and elimination from the body of the other medication.
Timeline
- Start
- 2011-03
- Primary completion
- 2011-07
- Completion
- 2011-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Artemether | Small molecule | 80 mg | — |
| Subject | Darunavir | Small molecule | 600 mg | — |
| Subject | Etravirine | Small molecule | 200 mg | — |
| Subject | Ritonavir | Other / unclassified | 100 mg | — |
| Subject | lumefantrine | Small molecule | 480 mg | — |