drugset / Trial / NCT02048891

Ovulation Trigger With hCG Compared to GnRH Agonist in Patients With Repeated IVF Failures

NCT02048891

Phase 4 Completed 3 enrolled Rambam Health Care Campus
RandomizedParallel-groupOpen-labelTreatment

Summary

Ovulation trigger is needed in in vitro fertilization (IVF) to get mature eggs. Routinely, human chorionic gonadotropin (hCG) is used for that purpose given its similarity to the natural hormone that does this job in a natural cycle (luteinizing hormone, LH). In a natural cycle another hormone takes part in the process (follicle stimulating hormone, FSH). To induce a natural-like ovulation surge that includes LH and FSH , gonadotropin releasing hormone (GnRH) agonist can be given. The purpose of this study is to find out which approach may work better in IVF patients who experienced 4 IVF failures.

Timeline

Start
2014-10
Primary completion
2015-01
Completion
2015-04

Drugs

EvaluationDrugModalityDoseRoute
Subject Decapeptyl Unknown 0.2 mg
Comparator human chorionic gonadotropin Protein / enzyme biologic 250 ug
Comparator human chorionic gonadotropin Protein / enzyme biologic 1500 iu
Comparator Progesterone Other / unclassified Other

Indications