drugset / Trial / NCT02048891
Ovulation Trigger With hCG Compared to GnRH Agonist in Patients With Repeated IVF Failures
RandomizedParallel-groupOpen-labelTreatment
Summary
Ovulation trigger is needed in in vitro fertilization (IVF) to get mature eggs. Routinely, human chorionic gonadotropin (hCG) is used for that purpose given its similarity to the natural hormone that does this job in a natural cycle (luteinizing hormone, LH). In a natural cycle another hormone takes part in the process (follicle stimulating hormone, FSH). To induce a natural-like ovulation surge that includes LH and FSH , gonadotropin releasing hormone (GnRH) agonist can be given. The purpose of this study is to find out which approach may work better in IVF patients who experienced 4 IVF failures.
Timeline
- Start
- 2014-10
- Primary completion
- 2015-01
- Completion
- 2015-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Decapeptyl | Unknown | 0.2 mg | — |
| Comparator | human chorionic gonadotropin | Protein / enzyme biologic | 250 ug | — |
| Comparator | human chorionic gonadotropin | Protein / enzyme biologic | 1500 iu | — |
| Comparator | Progesterone | Other / unclassified | — | Other |