drugset / Trial / NCT02111447

Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI

NCT02111447

Phase 4 Terminated 6 enrolled State University of New York at Buffalo
RandomizedFactorialDouble-blindPrevention

Summary

Children who receive general anesthesia may become agitated (emergence delirium) in the recovery period. This occurs more often after inhalational anesthetics, particularly sevoflurane and desflurane than after propofol. However, agitation after anesthesia in children may be difficult to distinguish from pain; accordingly studies are ideally designed during MRI to obviate the contribution of pain during emergence. Airway complications have been reported after LMA and isoflurane more commonly than with IV propofol and nasal prongs. Whether the airway complications were due to the LMA or the isoflurane was unclear. Therefore, this study was designed to study the incidence of 1. agitation after sevoflurane compared with IV propofol and 2. airway complications after LMA or nasal prongs.

Timeline

Start
2014-01
Primary completion
2014-12
Completion
2014-12

Drugs

EvaluationDrugModalityDoseRoute
Comparator Isoflurane Other / unclassified 2 % Inhaled
Comparator Propofol Small molecule 200 ug/kg Intravenous
Comparator Sevoflurane Other / unclassified 3 % Inhaled

Indications