Prophylactic Ethanol Lock Therapy (ELT) in Patients on Home Parenteral Nutrition

Summary

This study is being implemented to identify the role of prophylactic use of ethanol lock in adult patients on home parenteral nutrition (HPN). Central catheter related blood stream infection is a major complication in patients on HPN. The investigators hypothesize that the prophylactic use of ELT will decrease the number of catheter related blood stream infections compared to the control group. The investigators further hypothesize that with the introduction of prophylactic ELT, the number of infections will decrease.

Timeline

Start

2014-07

Primary completion

2016-10

Completion

2016-10

Outcome

Missed primary endpoint

Stopped: “Publication of guidelines advising against the use of ethanol locks.”

paper Four patients in the ELT group and one patient in the control arm had a CRBSI (p = 0.17). PMID 28576557 ↗

paper This study did not show improvement in the rate of CRBSI with ELT in all patients started on HPN. PMID 28576557 ↗

Publications

• Results Salonen BR, Bonnes SL, Vallumsetla N, Varayil JE, Mundi MS, Hurt RT. A prospective double blind randomized controlled study on the use of ethanol locks in HPN patients. Clin Nutr. 2018 Aug;37(4):1181-1185. doi: 10.1016/j.clnu.2017.05.009. Epub 2017 May 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ethanol	Other / unclassified	3 ml	Other
Comparator	Heparin	Other / unclassified	3 ml	Other
Background	sodium chloride	Unknown	—	Other

Indications

No indication recorded.