drugset / Trial / NCT02251119
The Pharmacodynamic/Pharmacokinetic Interaction of Tipranavir and Ritonavir With Loperamide in Healthy Volunteers
Parallel-groupOpen-labelTreatment
Summary
The objective of the study was to determine if the co-administration of loperamide (LOP) with tipranavir (TPV), ritonavir (RTV), or TPV plus RTV (TPV/r) caused a clinically significant change in the respiratory response to carbon dioxide (CO2), defined as a 10% decrease in the area under the pharmacodynamic effect/time curve or at least a 25% decrease in at least one pharmacodynamic time point.
Timeline
- Start
- 2002-07
- Primary completion
- 2003-01
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Loperamide | Small molecule | — | — |
| Subject | Ritonavir | Other / unclassified | — | — |
| Subject | Tipranavir | Small molecule | — | — |
Indications
No indication recorded.