A Study to Evaluate the Efficacy and Safety of Mizoribine in the Treatment of Lupus Nephritis

Summary

To demonstrate that the treatment effect in lupus nephritis of MZR is non-inferior to that of standard therapy CTX through analyzing overall remission rate after treatment.

Timeline

Start

2014-11

Primary completion

2019-03

Completion

2019-03

Publications

• Dong Z, Luo P, Sun S, Ni Z, He Y, Huang X, Liu Z, Wu Z, Zhang X, Liao Y, Zhao J, Lin H, Zhang X, Fu R, Ding G, Xu Y, Wang L, Xiao Y, Shi S, Zuo X, Li Z, Qiao L, Wang R, Li W, Wan J, Li Y, Guan T, Deng X, Wu X, Zheng H, Chen J, He L, Yamaguchi S, Wang H, Cai GY, Zhang L, Chen X. Mizoribine or Cyclophosphamide for Lupus Nephritis: A Randomized Clinical Trial. JAMA Netw Open. 2025 Mar 3;8(3):e250648. doi: 10.1001/jamanetworkopen.2025.0648.

Drugs

Indications