Research on New Regimens for Retreatment Pulmonary Tuberculosis

Phase 4 Unknown 864 enrolled Shanghai Pulmonary Hospital, Shanghai, China Centers for Disease Control and Prevention · collab Jiangsu Province Centers for Disease Control and Prevention · collab Shanghai Center for Disease Control and Prevention · collab Zhejiang University · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

Multi-center, prospective study is performed to investigate the efficacy of new short-course regimen for retreatment pulmonary tuberculosis patients. To obtain optimized short-course regimen, decrease treatment cost and improve success rate.

Timeline

Start: 2013-06
Primary completion: 2015-12
Completion: 2016-12

Publications

Yan L, Kan X, Zhu L, Xu K, Yin J, Jie L, Li Y, Yue J, Cui W, Du J, Wang L, Tan S, Jiang X, Zeng Z, Xu S, Wang L, Chen Y, He W, Gao X, Bai D, Zhao C, Yan X, Zhu Y, Fan Y, Xie L, Deng A, Zhang Q, Xiao H. Short-course Regimen for Subsequent Treatment of Pulmonary Tuberculosis: A Prospective, Randomized, Controlled Multicenter Clinical Trial in China. Clin Ther. 2018 Mar;40(3):440-449. doi: 10.1016/j.clinthera.2018.01.013. Epub 2018 Mar 6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ethambutol	Small molecule	0.75 g	Oral
Comparator	Isoniazid	Small molecule	0.3 g	Oral
Subject	Isoniazid Aminosalicylate	Unknown	0.3 g	Oral
Subject	Moxifloxacin	Small molecule	0.4 g	Oral
Subject	Pyrazinamide	Small molecule	0.5 g	Oral
Subject	Rifabutin	Small molecule	0.3 g	Oral
Comparator	Rifampin	Small molecule	0.45 g	Oral
Comparator	Rifampin	Small molecule	0.6 g	Oral
Comparator	streptomycin	Other / unclassified	0.75 g	Intramuscular

Research on New Regimens for Retreatment Pulmonary Tuberculosis

Summary

Timeline

Publications

Drugs

Indications