Effect of Dapagliflozin on 24-hour Blood Glucose in T2DM Patients Inadequately Controlled With Either Metformin Or Insulin

Summary

Effect of Dapagliflozin on 24-hour Blood Glucose in Type 2 Diabetes Patients Inadequately Controlled With Either Metformin Or Insulin

Timeline

Start

2015-05

Primary completion

2015-10

Completion

2015-10

Outcome

Met primary endpoint

registry LEAST_SQUARES_MEAN Dapagliflozin: -18.2 (Standard Error 4.33) mg/dL LEAST_SQUARES_MEAN Placebo: 5.8 (Standard Error 4.25) mg/dL NCT02429258 ↗

registry Dapagliflozin vs Placebo; p <0.001; Mean Difference (Final Values) -24.0 (95% CI -36.1 to -12.0) NCT02429258 ↗

Publications

• Henry RR, Strange P, Zhou R, Pettus J, Shi L, Zhuplatov SB, Mansfield T, Klein D, Katz A. Effects of Dapagliflozin on 24-Hour Glycemic Control in Patients with Type 2 Diabetes: A Randomized Controlled Trial. Diabetes Technol Ther. 2018 Nov;20(11):715-724. doi: 10.1089/dia.2018.0052. Epub 2018 Sep 14.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Forxiga	Unknown	10 mg	—
Background	Insulin	Protein / enzyme biologic	30 iu	—
Background	Metformin	Small molecule	1500 mg	—

Indications