drugset / Trial / NCT02467673
Nanoparticulate Versus Micronized Steroids Delivery for Transdermal Hormone Replacement Therapy
Phase 2
Completed
185 enrolled
University Potiguar
Federal University of São Paulo · collabInBios International, Inc. · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The study aims to asses the effects of micronized (MIC) and nanoparticulate (NANO) transdermal hormone therapy (THT) on blood pressure, ultra-sensitive C-reactive protein (CRP), and cardiovascular risk factors in postmenopausal women.
Timeline
- Start
- 2012-01
- Primary completion
- 2012-03
- Completion
- 2012-07
Publications
- Background Botelho MA, Martins JG, Ruela RS, Queiroz DB, Ruela WS. Nanotechnology in ligature-induced periodontitis: protective effect of a doxycycline gel with nanoparticules. J Appl Oral Sci. 2010 Jul-Aug;18(4):335-42. doi: 10.1590/s1678-77572010000400003.
- Results Botelho MA, Queiroz DB, Barros G, Guerreiro S, Fechine P, Umbelino S, Lyra A, Borges B, Freitas A, Queiroz DC, Ruela R, Almeida JG, Quintans L Jr. Nanostructured transdermal hormone replacement therapy for relieving menopausal symptoms: a confocal Raman spectroscopy study. Clinics (Sao Paulo). 2014 Feb;69(2):75-82. doi: 10.6061/clinics/2014(02)01.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Estradiol | Other / unclassified | 2.5 mg | Other |
| Comparator | Progesterone | Other / unclassified | 100 mg | Other |
Indications
No indication recorded.