drugset / Trial / NCT02486328
The Effect of Different Sedation Regimes on Cognitive Function in Lower Gastrointestinal System Endoscopy
RandomizedParallel-groupSingle-blindDiagnostic
Summary
There are different sedation regimes for lower gastrointestinal system endoscopy which can be administered by anesthesiologists and non-anesthesiologists. This study aims to compare the effects of propofol/remifentanil combination and midazolam/meperidine combination on early cognitive function following lower gastrointestinal system endoscopies.
Timeline
- Start
- 2015-05
- Primary completion
- 2015-06
- Completion
- 2015-06
Outcome
Met primary endpoint
registry analysis (unspecified test); Group MM vs Group RP; p = 0.001; Wilcoxon (Mann-Whitney) NCT02486328 ↗
Publications
- Results Cohen LB, Dubovsky AN, Aisenberg J, Miller KM. Propofol for endoscopic sedation: A protocol for safe and effective administration by the gastroenterologist. Gastrointest Endosc. 2003 Nov;58(5):725-32. doi: 10.1016/s0016-5107(03)02010-8.
- Results Ferreira AO, Cravo M. Sedation in gastrointestinal endoscopy: Where are we at in 2014? World J Gastrointest Endosc. 2015 Feb 16;7(2):102-9. doi: 10.4253/wjge.v7.i2.102.
- Results Padmanabhan U, Leslie K, Eer AS, Maruff P, Silbert BS. Early cognitive impairment after sedation for colonoscopy: the effect of adding midazolam and/or fentanyl to propofol. Anesth Analg. 2009 Nov;109(5):1448-55. doi: 10.1213/ane.0b013e3181a6ad31. Epub 2009 Jul 17.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Meperidine | Unknown | 20 mg | — |
| Subject | Midazolam | Small molecule | 2 mg | — |
| Subject | Propofol | Small molecule | 100 ug/kg | — |
| Subject | Remifentanil | Small molecule | 1 ug/kg | — |