Drugs / Meperidine
Meperidine
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | DEMEROL | — | 1942-11-10 | fda.gov ↗ |
Trials 13 · a red edge is where a trial was stopped
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| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 21 trial | ||||||
| Phase 2 | NCT01236651 | Nov 2010 → Apr 2011 | — | Ain Shams University | Unknown | No outcome recorded |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT03260283 | Aug 2017 → Nov 2018 | — | Saint Savvas Anticancer Hospital | Completed | No outcome recorded |
| Phase 32 trials | ||||||
| Phase 3 | NCT05126459 | Feb 2022 → Apr 2023 | anxiety, dental caries | Loma Linda University | Completed | No outcome recorded |
| Phase 3 | NCT00163553 | Dec 2004 → ? | sciatica | Austin Health | Unknown | No outcome recorded |
| Phase 43 trials | ||||||
| Phase 4 | NCT05110469 | Feb → Jun 2021 | benign shuddering attacks | AnestesiaR | Completed | No outcome recorded |
| Phase 4 | NCT02486328 | May → Jun 2015 | cognitive disorder, digestive system disorder | Ufuk University | Completed | No outcome recorded |
| Phase 4 | NCT00596414 | May 2003 → Oct 2005 | anxiety, cirrhosis of liver, hepatitis | Erasme University Hospital | Completed | No outcome recorded |
| Phase not applicable6 trials | ||||||
| — | NCT07596004 | Mar → Jun 2026 overdue | — | Shaheed Mohtarma Benazir Bhutto Institue of Trauma | Active not recruiting | No outcome recorded |
| — | NCT04446715 | Oct 2020 → Aug 2021 | — | Makassed General Hospital | Unknown | No outcome recorded |
| — | NCT01741259 | Aug 2013 → Apr 2015 | — | Mercy Research | Completed | No outcome recorded |
| — | NCT01840371 | Apr 2013 → Mar 2014 | — | Yonsei University | Completed | No outcome recorded |
| — | NCT01547520 | Jun 2011 → Feb 2012 | — | Dalin Tzu Chi General Hospital | Completed | No outcome recorded |
| — | NCT00296751 | Mar → Dec 2006 | — | Rambam Health Care Campus | Completed | No outcome recorded |
Also used as a comparator or background therapy in 79 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 01 trial | ||||||
| Phase 0 | NCT07711522 Background | Aug 2026 → Jul 2027 expected | — | Istanbul Medipol University Hospital | Not yet recruiting | No outcome recorded |
| Phase 12 trials | ||||||
| Phase 1 | NCT05035407 Background | Mar 2022 → Jul 2025 | — | National Cancer Institute (NCI) | Terminated | No outcome recorded |
| Phase 1 | NCT02867800 Background | Jul 2016 → Dec 2021 | graft versus host disease, sickle cell disease | Monica Bhatia | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT02858310 Background | Jan 2017 → Jul 2025 | cervical intraepithelial neoplasia, human papilloma virus infection, in situ carcinoma, vulvar neoplasm | National Cancer Institute (NCI) | Completed | No outcome recorded |
| Phase 210 trials | ||||||
| Phase 2 | NCT06326944 Comparator | Apr → Sep 2024 | — | Kasr El Aini Hospital | Completed | No outcome recorded |
| Phase 2 | NCT03456817 Background | Jul 2020 → May 2025 | graft versus host disease | AHS Cancer Control Alberta | Terminated | No outcome recorded |
| Phase 2 | NCT03968146 Background | Jun → Nov 2019 | idiopathic scoliosis | Kasr El Aini Hospital | Completed | No outcome recorded |
| Phase 2 | NCT02441673 Comparator | Oct 2018 → Jan 2019 | benign shuddering attacks | Lagos State Health Service Commission | Unknown | No outcome recorded |
| Phase 2 | NCT02619019 Comparator | Nov 2015 → Jun 2016 | benign shuddering attacks | Assiut University | Completed | No outcome recorded |
| Phase 2 | NCT02578251 Comparator | Oct 2015 → Mar 2016 | — | Ain Shams Maternity Hospital | Unknown | No outcome recorded |
| Phase 2 | NCT02557087 Comparator | Sep 2015 → Mar 2016 | — | Ain Shams Maternity Hospital | Unknown | No outcome recorded |
| Phase 2 | NCT02549118 Comparator | Sep 2015 → Mar 2016 | obstetric disorder | Ain Shams Maternity Hospital | Unknown | No outcome recorded |
| Phase 2 | NCT02651792 Comparator | Jan 2015 → Apr 2016 | — | Assiut University | Completed | No outcome recorded |
| Phase 2 | NCT02382432 Comparator | Dec 2013 → Dec 2014 | — | Assiut University | Completed | No outcome recorded |
| Phase 2/34 trials | ||||||
| Phase 2/3 | NCT06082076 Comparator | Nov 2023 → Nov 2024 | — | Assiut University | Unknown | No outcome recorded |
| Phase 2/3 | NCT03167905 Comparator | Jun 2017 → Jul 2021 overdue | postpartum depression | KK Women's and Children's Hospital | Active not recruiting | No outcome recorded |
| Phase 2/3 | NCT03652116 Comparator | Apr 2017 → Jun 2018 | obstetric disorder | Ain Shams University | Completed | No outcome recorded |
| Phase 2/3 | NCT02707250 Comparator | Mar 2015 → Feb 2016 | — | Iuliu Hatieganu University of Medicine and Pharmacy | Unknown | No outcome recorded |
| Phase 36 trials | ||||||
| Phase 3 | NCT07299630 Background | Dec 2025 → May 2026 | — | Ain Shams University | Completed | No outcome recorded |
| Phase 3 | NCT06775431 Comparator | Dec 2024 → Feb 2025 overdue | — | Alexandria University | Recruiting | No outcome recorded |
| Phase 3 | NCT03115047 Comparator | May 2017 → Aug 2020 | — | University of Montreal Hospital Centre (CHUM) | Completed | No outcome recorded |
| Phase 3 | NCT04686058 Comparator | Mar → Dec 2014 | — | Universiti Kebangsaan Malaysia Medical Centre | Completed | No outcome recorded |
| Phase 3 | NCT01833312 Background | Jul 2013 → Jul 2018 | ischemic stroke | University of Erlangen-Nürnberg Medical School | Terminated | No outcome recorded |
| Phase 3 | NCT01858090 Comparator | Jan → Oct 2009 | — | Baskent University | Completed | No outcome recorded |
| Phase 421 trials | ||||||
| Phase 4 | NCT06736938 Comparator | Apr 2025 → Apr 2027 expected | — | Fondazione Andrea Cesalpino Arezzo ONLUS | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT06172920 Comparator | Dec 2023 → Nov 2024 | respiratory system disorder | Baskent University | Unknown | No outcome recorded |
| Phase 4 | NCT05284409 Comparator | Jul → Sep 2022 | benign shuddering attacks | Ain Shams University | Completed | No outcome recorded |
| Phase 4 | NCT05386121 Comparator | May → Sep 2022 | — | Cairo University | Unknown | No outcome recorded |
| Phase 4 | NCT05303311 Comparator | Jan 2022 → Jan 2024 | — | Zagazig University | Completed | No outcome recorded |
| Phase 4 | NCT04735965 Comparator | Jul 2021 → Jul 2022 | coronary artery disorder | Qianfoshan Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT04068948 Comparator | Jun 2019 → Dec 2022 | dental caries | University of Washington | Completed | No outcome recorded |
| Phase 4 | NCT03032458 Comparator | Jan → Oct 2017 | urolithiasis | Mansoura University | Completed | No outcome recorded |
| Phase 4 | NCT02494180 Comparator | Mar 2016 → Feb 2018 | infertility disorder | Kwong Wah Hospital | Completed | No outcome recorded |
| Phase 4 | NCT02493192 Comparator | Jul → Dec 2015 | — | Hospital General Universitario Gregorio Marañon | Unknown | No outcome recorded |
| Phase 4 | NCT02475824 Background | May 2015 → Nov 2016 | — | Dankook University | Completed | No outcome recorded |
| Phase 4 | NCT02179294 Comparator | May 2014 → Sep 2016 | — | University of Birmingham | Completed | No outcome recorded |
| Phase 4 | NCT02027311 Background | Apr → Aug 2013 | cholangiocarcinoma, choledocholithiasis, malignant pancreatic neoplasm, pancreatitis | Cheju Halla General Hospital | Completed | No outcome recorded |
| Phase 4 | NCT01693185 Comparator | Dec 2012 → Feb 2013 | — | Konkuk University Medical Center | Completed | No outcome recorded |
| Phase 4 | NCT02684942 Comparator | Oct 2012 → Mar 2013 | — | Chulabhorn Cancer Center | Completed | No outcome recorded |
| Phase 4 | NCT01558622 Comparator | Mar → May 2012 | — | Kavaklıdere Umut Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT01555671 Comparator | Jan → May 2012 | — | Kanuni Sultan Suleyman Training and Research Hospital | Completed | No outcome recorded |
| Phase 4 | NCT01394731 Comparator | Dec 2010 → Jul 2011 | — | King Abdulaziz University | Completed | No outcome recorded |
| Phase 4 | NCT01709422 Comparator | Jun 2010 → Nov 2012 | hepatobiliary disorder | Prince of Songkla University | Completed | No outcome recorded |
| Phase 4 | NCT01229527 Comparator | Apr 2009 → Dec 2010 | — | Ospedale San Raffaele | Completed | No outcome recorded |
| Phase 4 | NCT00937924 Background | Feb 2008 → Jun 2012 | — | University of California, Irvine | Completed | No outcome recorded |
| Phase not applicable34 trials | ||||||
| — | NCT07278050 Comparator | Jan → Sep 2026 expected | — | Medipol University | Recruiting | No outcome recorded |
| — | NCT07264309 Comparator | Nov 2025 → Dec 2026 expected | — | Zohar Nachum | Recruiting | No outcome recorded |
| — | NCT06962085 Comparator | Sep 2025 → Jan 2026 | — | Adiyaman University | Completed | No outcome recorded |
| — | NCT06866054 Background | Apr → Aug 2025 overdue | arthropathy | Kahramanmaras Sutcu Imam University | Recruiting | No outcome recorded |
| — | NCT05270434 Background | Mar → Oct 2025 | chronic pancreatitis | Changhai Hospital | Completed | No outcome recorded |
| — | NCT06627816 Comparator | Jan → Jun 2025 | benign shuddering attacks | Kasr El Aini Hospital | Completed | No outcome recorded |
| — | NCT06546839 Comparator | Aug 2024 → Jun 2025 | lung cancer | Medipol University | Completed | No outcome recorded |
| — | NCT05972083 Background | Aug 2023 → Oct 2024 | breast disorder | Medipol University | Completed | No outcome recorded |
| — | NCT05972122 Background | Aug 2023 → Jun 2024 | lung disorder | Medipol University | Withdrawn | No outcome recorded |
| — | NCT05904912 Background | Jun → Dec 2023 | aortic valve stenosis | Medipol University | Completed | No outcome recorded |
| — | NCT05621161 Comparator | Nov 2022 → Aug 2023 | osteoarthritis, knee | Mursel Ekinci | Completed | No outcome recorded |
| — | NCT05566561 Comparator | Oct 2022 → Aug 2025 | disease of bone structure, osteoarthritis, knee | Medipol University | Completed | No outcome recorded |
| — | NCT05696886 Comparator | Jan 2021 → Dec 2022 | — | Mansoura University | Completed | No outcome recorded |
| — | NCT04719507 Comparator | Jan 2021 → Jan 2022 | — | Cairo University | Unknown | No outcome recorded |
| — | NCT04133571 Background | May 2019 → Dec 2020 | urinary bladder disorder | Kaohsiung Medical University Chung-Ho Memorial Hospital | Unknown | No outcome recorded |
| — | NCT03866733 Comparator | Mar 2019 → Sep 2020 | — | Ain Shams University | Completed | No outcome recorded |
| — | NCT04744727 Comparator | Mar 2019 → Mar 2020 | — | Menoufia University | Completed | No outcome recorded |
| — | NCT03422354 Comparator | Feb → May 2018 | — | Cairo University | Completed | No outcome recorded |
| — | NCT03413163 Background | Feb → Apr 2018 | — | Maltepe University | Completed | No outcome recorded |
| — | NCT02858622 Comparator | Dec 2016 → Jan 2019 | kidney failure | Cairo University | Completed | No outcome recorded |
| — | NCT02971475 Background | Nov 2016 → May 2019 | chronic pancreatitis | Changhai Hospital | Unknown | No outcome recorded |
| — | NCT02783508 Comparator | Aug 2016 → May 2019 | — | HaEmek Medical Center, Israel | Completed | No outcome recorded |
| — | NCT02625181 Background | Jul 2016 → Nov 2017 | — | Vanderbilt University | Completed | No outcome recorded |
| — | NCT03780556 Comparator | Jan 2016 → Jul 2017 | urinary tract obstruction | Ain Shams University | Completed | No outcome recorded |
| — | NCT02393144 Background | Feb 2015 → Jan 2017 | pregnancy disorder | Ankara University | Unknown | No outcome recorded |
| — | NCT02037802 Comparator | Mar → Oct 2014 | kidney failure | Cairo University | Completed | No outcome recorded |
| — | NCT02012244 Background | Jan → Dec 2014 | colorectal cancer | Severance Hospital | Completed | No outcome recorded |
| — | NCT02016976 Comparator | Jan → Aug 2014 | — | Hillel Yaffe Medical Center | Unknown | No outcome recorded |
| — | NCT01948921 Comparator | Sep 2013 → Mar 2017 | — | Dalin Tzu Chi General Hospital | Completed | No outcome recorded |
| — | NCT02039453 Comparator | Sep 2013 → Aug 2015 | — | Yonsei University | Unknown | No outcome recorded |
| — | NCT01997788 Background | Aug → Oct 2013 | renal cell carcinoma | Seoul National University Hospital | Completed | No outcome recorded |
| — | NCT01993589 Comparator | Nov 2012 → Nov 2013 | — | Kayseri Education and Research Hospital | Completed | No outcome recorded |
| — | NCT00848861 Comparator | Feb → Jun 2006 | — | University of Alberta | Completed | No outcome recorded |
| — | NCT00566683 Comparator | Jul 2005 → Jun 2006 | — | North District Hospital | Completed | No outcome recorded |
Evidence & citations 9 cited values
Every value below carries the sentence it was read from. 92 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | meperidine | “If the NRS score is ≥ 4, 0.5 mg kg-1 iv meperidine will be administered as a rescue analgesic.” NCT05904912 ↗45“If the NRS score is ≥ 4, 0.5 mg kg-1 iv meperidine will be administered as a rescue analgesic.” NCT06546839 ↗ “If the NRS score is ≥ 4, 0.5 mg kg-1 iv meperidine will be administered as a rescue analgesic.” NCT05972122 ↗ “If the NRS score is ≥ 4, 0.5 mg kg-1 IV meperidine will be administered as a rescue analgesic.” NCT07278050 ↗ “Group P (n =80) will receive pethidine (meperidine) 0.5 mg/kg i.v. (Ampoules of 50 mg/1 ml).” NCT06627816 ↗ “Intravenous meperidine administration at 0.5 mg / kg rescue analgesia was determined” NCT03413163 ↗ “Hydroxyzine (1.5- 2mg/kg) + Meperidine (1.5 -2 mg/kg) + Midazolam (0.5- 0.75 mg/kg)” NCT05126459 ↗ “If the VAS score will be ≥ 4, 0,5 mg/kg-1 meperidine IV will be administered.” NCT05621161 ↗ “Meperidine 25-50 mg IVPB every 4 hours will be given as needed for rigors.” NCT03456817 ↗ “0.5 mg kg-1 iv meperidine will be administered as a rescue analgesic.” NCT05972083 ↗ “0.5 mg kg-1 iv meperidine will be administered as a rescue analgesic.” NCT06866054 ↗ “0.5 mg kg-1 iv meperidine will be administered as a rescue analgesic.” NCT05566561 ↗ “Patients are receiving meperidine under thoracic surgery” NCT06172920 ↗ “Propofol Meperidine : 25 mg IV just before procedure” NCT01840371 ↗ “Pethidine (meperidine) is a unique opioid.” NCT05303311 ↗ |
| Known as | Demerol | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01997788 ↗ |
| Known as | Dexmeditomidine | ClinicalTrials.gov intervention name — accepted as the source's own label NCT07596004 ↗ |
| Known as | pethidine | “Group P (n =80) will receive pethidine (meperidine) 0.5 mg/kg i.v. (Ampoules of 50 mg/1 ml).” NCT06627816 ↗44“fentanyl based patient-controlled analgesia + additional pethidine for postoperative 48 hour” NCT02012244 ↗ “intravenous paracetamol( 1gram ) and pethidine IV (50 mg ) will be added when needed.” NCT03422354 ↗ “Postoperatively pethidine 50 mg IV will be administered for VAS score greater than 4” NCT07299630 ↗ “The forth group consisted of 25 participants receiving 100 mg pethidine.” NCT01993589 ↗ “then intravenous pethidine till 48 hours after surgery” NCT03866733 ↗ “Group P received pethidine 50 mg IV.” NCT03780556 ↗ “intravenous pethidine 0.25 mg/kg” NCT04133571 ↗ “"Meperidine" (pethidine®)” NCT02475824 ↗ |
| Known as | pethidine HCL | “Meperidine (50mg. 25mg for patients aged ≥70 years; pethidine HCL, Hana Pharm Co., Seoul, Republic of Korea).” NCT02475824 ↗ |
| Known as | Pethidine Hydrochloride | “Pethidine Hydrochloride 50 Mg/mL Solution for Injection” NCT06775431 ↗ |
| Action | Activate | “Pethidine is one of the most frequently used opiate agonists.” NCT02783508 ↗ |
| Modality | Small molecule | “synthetic opioid analgesic” NCT01558622 ↗ |
| Route | Other | “continuous infusion of epidural pethidine through a surgically-placed catheter” NCT00163553 ↗ |