Meperidine

also known as pethidine · Pethidine Hydrochloride · Demerol · pethidine HCL

Developed for: anxiety · benign shuddering attacks · sciatica · obstetric disorder · urinary tract obstruction
Investigated by: Ain Shams University · AnestesiaR · Austin Health · Dalin Tzu Chi General Hospital · Erasme University Hospital · Loma Linda University
+6 more
· Makassed General Hospital · Mercy Research · Rambam Health Care Campus · Saint Savvas Anticancer Hospital · Ufuk University · Yonsei University

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Approved	US (FDA)	DEMEROL	—	1942-11-10	fda.gov ↗

Trials 12

today

US approved 1942

NCT05126459 · Ph 3 NCT05110469 · Ph 4 NCT04446715 · not/applicable NCT03260283 · Ph 2/3 NCT02486328 · Ph 4 NCT01741259 · not/applicable NCT01840371 · not/applicable NCT01547520 · not/applicable NCT01236651 · Ph 2 NCT00296751 · not/applicable NCT00163553 · Ph 3 NCT00596414 · Ph 4

19411942194319441945194619471948194919501951195219531954195519561957195819591960196119621963196419651966196719681969197019711972197319741975197619771978197919801981198219831984198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 21 trial
Phase 2	NCT01236651	Nov 2010 → Apr 2011	—	Ain Shams University	Unknown	No outcome recorded
Phase 2/31 trial
Phase 2/3	NCT03260283	Aug 2017 → Nov 2018	—	Saint Savvas Anticancer Hospital	Completed	No outcome recorded
Phase 32 trials
Phase 3	NCT05126459	Feb 2022 → Apr 2023	anxiety, dental caries	Loma Linda University	Completed	No outcome recorded
Phase 3	NCT00163553	Dec 2004 → ?	sciatica	Austin Health	Unknown	No outcome recorded
Phase 43 trials · 1 met primary
Phase 4	NCT05110469	Feb → Jun 2021	benign shuddering attacks	AnestesiaR	Completed	No outcome recorded
Phase 4	NCT02486328	May → Jun 2015	cognitive disorder, digestive system disorder	Ufuk University	Completed	Met primary
Phase 4	NCT00596414	May 2003 → Oct 2005	anxiety, cirrhosis of liver, hepatitis	Erasme University Hospital	Completed	No outcome recorded
Phase not applicable5 trials · 2 met primary
—	NCT04446715	Oct 2020 → Aug 2021	—	Makassed General Hospital	Unknown	Met primary
—	NCT01741259	Aug 2013 → Apr 2015	—	Mercy Research	Completed	No outcome recorded
—	NCT01840371	Apr 2013 → Mar 2014	—	Yonsei University	Completed	No outcome recorded
—	NCT01547520	Jun 2011 → Feb 2012	—	Dalin Tzu Chi General Hospital	Completed	Met primary
—	NCT00296751	Mar → Dec 2006	—	Rambam Health Care Campus	Completed	No outcome recorded
Comparator or background therapy80 trials
Phase 0	NCT07711522 Background	Aug 2026 → Jul 2027 expected	—	Istanbul Medipol University Hospital	Not yet recruiting	No outcome recorded
Phase 1	NCT05035407 Background	Mar 2022 → Jul 2025	—	National Cancer Institute (NCI)	Terminated	No outcome recorded
Phase 1	NCT02867800 Background	Jul 2016 → Dec 2021	graft versus host disease, sickle cell disease	Monica Bhatia	Completed	No outcome recorded
Phase 1/2	NCT02858310 Background	Jan 2017 → Jul 2025	cervical intraepithelial neoplasia, human papilloma virus infection, in situ carcinoma, vulvar neoplasm	National Cancer Institute (NCI)	Completed	No outcome recorded
Phase 2	NCT06326944 Comparator	Apr → Sep 2024	—	Kasr El Aini Hospital	Completed	No outcome recorded
Phase 2	NCT03456817 Background	Jul 2020 → May 2025	graft versus host disease	AHS Cancer Control Alberta	Terminated	No outcome recorded Stop: Enrollment
Phase 2	NCT03968146 Background	Jun → Nov 2019	idiopathic scoliosis	Kasr El Aini Hospital	Completed	No outcome recorded
Phase 2	NCT02441673 Comparator	Oct 2018 → Jan 2019	benign shuddering attacks	Lagos State Health Service Commission	Unknown	No outcome recorded
Phase 2	NCT02619019 Comparator	Nov 2015 → Jun 2016	benign shuddering attacks	Assiut University	Completed	No outcome recorded
Phase 2	NCT02578251 Comparator	Oct 2015 → Mar 2016	—	Ain Shams Maternity Hospital	Unknown	No outcome recorded
Phase 2	NCT02549118 Comparator	Sep 2015 → Mar 2016	obstetric disorder	Ain Shams Maternity Hospital	Unknown	No outcome recorded
Phase 2	NCT02557087 Comparator	Sep 2015 → Mar 2016	—	Ain Shams Maternity Hospital	Unknown	No outcome recorded
Phase 2	NCT02651792 Comparator	Jan 2015 → Apr 2016	—	Assiut University	Completed	No outcome recorded
Phase 2	NCT02382432 Comparator	Dec 2013 → Dec 2014	—	Assiut University	Completed	No outcome recorded
Phase 2/3	NCT06082076 Comparator	Nov 2023 → Nov 2024	—	Assiut University	Unknown	No outcome recorded
Phase 2/3	NCT03167905 Comparator	Jun 2017 → Jul 2021 overdue	postpartum depression	KK Women's and Children's Hospital	Active not recruiting	Missed primary
Phase 2/3	NCT03652116 Comparator	Apr 2017 → Jun 2018	obstetric disorder	Ain Shams University	Completed	No outcome recorded
Phase 2/3	NCT02707250 Comparator	Mar 2015 → Feb 2016	—	Iuliu Hatieganu University of Medicine and Pharmacy	Unknown	No outcome recorded
Phase 3	NCT07299630 Background	Dec 2025 → May 2026	—	Ain Shams University	Completed	No outcome recorded
Phase 3	NCT06775431 Comparator	Dec 2024 → Feb 2025 overdue	—	Alexandria University	Recruiting	No outcome recorded
Phase 3	NCT03115047 Comparator	May 2017 → Aug 2020	—	University of Montreal Hospital Centre (CHUM)	Completed	No outcome recorded
Phase 3	NCT04686058 Comparator	Mar → Dec 2014	—	Universiti Kebangsaan Malaysia Medical Centre	Completed	No outcome recorded
Phase 3	NCT01833312 Background	Jul 2013 → Jul 2018	ischemic stroke	University of Erlangen-Nürnberg Medical School	Terminated	No outcome recorded Stop: Enrollment
Phase 3	NCT01858090 Comparator	Jan → Oct 2009	—	Baskent University	Completed	No outcome recorded
Phase 4	NCT07855536 Comparator	Nov 2026 → Nov 2027 expected	benign shuddering attacks	Assiut University	Not yet recruiting	No outcome recorded
Phase 4	NCT06736938 Comparator	Apr 2025 → Apr 2027 expected	—	Fondazione Andrea Cesalpino Arezzo ONLUS	Not yet recruiting	No outcome recorded
Phase 4	NCT06172920 Comparator	Dec 2023 → Nov 2024	respiratory system disorder	Baskent University	Unknown	No outcome recorded
Phase 4	NCT05284409 Comparator	Jul → Sep 2022	benign shuddering attacks	Ain Shams University	Completed	No outcome recorded
Phase 4	NCT05386121 Comparator	May → Sep 2022	—	Cairo University	Unknown	No outcome recorded
Phase 4	NCT05303311 Comparator	Jan 2022 → Jan 2024	—	Zagazig University	Completed	No outcome recorded
Phase 4	NCT04735965 Comparator	Jul 2021 → Jul 2022	coronary artery disorder	Qianfoshan Hospital	Unknown	No outcome recorded
Phase 4	NCT04068948 Comparator	Jun 2019 → Dec 2022	dental caries	University of Washington	Completed	No outcome recorded
Phase 4	NCT03032458 Comparator	Jan → Oct 2017	urolithiasis	Mansoura University	Completed	No outcome recorded
Phase 4	NCT02494180 Comparator	Mar 2016 → Feb 2018	infertility disorder	Kwong Wah Hospital	Completed	No outcome recorded
Phase 4	NCT02493192 Comparator	Jul → Dec 2015	—	Hospital General Universitario Gregorio Marañon	Unknown	No outcome recorded
Phase 4	NCT02475824 Background	May 2015 → Nov 2016	—	Dankook University	Completed	No outcome recorded
Phase 4	NCT02179294 Comparator	May 2014 → Sep 2016	—	University of Birmingham	Completed	No outcome recorded
Phase 4	NCT02027311 Background	Apr → Aug 2013	cholangiocarcinoma, choledocholithiasis, malignant pancreatic neoplasm, pancreatitis	Cheju Halla General Hospital	Completed	Missed primary
Phase 4	NCT01693185 Comparator	Dec 2012 → Feb 2013	—	Konkuk University Medical Center	Completed	Met primary
Phase 4	NCT02684942 Comparator	Oct 2012 → Mar 2013	—	Chulabhorn Cancer Center	Completed	No outcome recorded
Phase 4	NCT01558622 Comparator	Mar → May 2012	—	Kavaklıdere Umut Hospital	Unknown	No outcome recorded
Phase 4	NCT01555671 Comparator	Jan → May 2012	—	Kanuni Sultan Suleyman Training and Research Hospital	Completed	No outcome recorded
Phase 4	NCT01394731 Comparator	Dec 2010 → Jul 2011	—	King Abdulaziz University	Completed	No outcome recorded
Phase 4	NCT01709422 Comparator	Jun 2010 → Nov 2012	hepatobiliary disorder	Prince of Songkla University	Completed	No outcome recorded
Phase 4	NCT01229527 Comparator	Apr 2009 → Dec 2010	—	Ospedale San Raffaele	Completed	No outcome recorded
Phase 4	NCT00937924 Background	Feb 2008 → Jun 2012	—	University of California, Irvine	Completed	No outcome recorded
—	NCT07278050 Comparator	Jan → Sep 2026 overdue	—	Medipol University	Recruiting	No outcome recorded
—	NCT07264309 Comparator	Nov 2025 → Dec 2026 expected	—	Zohar Nachum	Recruiting	No outcome recorded
—	NCT06962085 Comparator	Sep 2025 → Jan 2026	—	Adiyaman University	Completed	No outcome recorded
—	NCT06866054 Background	Apr → Aug 2025 overdue	arthropathy	Kahramanmaras Sutcu Imam University	Recruiting	No outcome recorded
—	NCT05270434 Background	Mar → Oct 2025	chronic pancreatitis	Changhai Hospital	Completed	No outcome recorded
—	NCT06627816 Comparator	Jan → Jun 2025	benign shuddering attacks	Kasr El Aini Hospital	Completed	No outcome recorded
—	NCT06546839 Comparator	Aug 2024 → Jun 2025	lung cancer	Medipol University	Completed	No outcome recorded
—	NCT05972083 Background	Aug 2023 → Oct 2024	breast disorder	Medipol University	Completed	No outcome recorded
—	NCT05972122 Background	Aug 2023 → Jun 2024	lung disorder	Medipol University	Withdrawn	No outcome recorded Stop: Enrollment
—	NCT05904912 Background	Jun → Dec 2023	aortic valve stenosis	Medipol University	Completed	No outcome recorded
—	NCT05621161 Comparator	Nov 2022 → Aug 2023	osteoarthritis, knee	Mursel Ekinci	Completed	No outcome recorded
—	NCT05566561 Comparator	Oct 2022 → Aug 2025	disease of bone structure, osteoarthritis, knee	Medipol University	Completed	No outcome recorded
—	NCT05696886 Comparator	Jan 2021 → Dec 2022	—	Mansoura University	Completed	No outcome recorded
—	NCT04719507 Comparator	Jan 2021 → Jan 2022	—	Cairo University	Unknown	No outcome recorded
—	NCT04133571 Background	May 2019 → Dec 2020	urinary bladder disorder	Kaohsiung Medical University Chung-Ho Memorial Hospital	Unknown	No outcome recorded
—	NCT03866733 Comparator	Mar 2019 → Sep 2020	—	Ain Shams University	Completed	No outcome recorded
—	NCT04744727 Comparator	Mar 2019 → Mar 2020	—	Menoufia University	Completed	No outcome recorded
—	NCT03422354 Comparator	Feb → May 2018	—	Cairo University	Completed	No outcome recorded
—	NCT03413163 Background	Feb → Apr 2018	—	Maltepe University	Completed	No outcome recorded
—	NCT02858622 Comparator	Dec 2016 → Jan 2019	kidney failure	Cairo University	Completed	No outcome recorded
—	NCT02971475 Background	Nov 2016 → May 2019	chronic pancreatitis	Changhai Hospital	Unknown	No outcome recorded
—	NCT02783508 Comparator	Aug 2016 → May 2019	—	HaEmek Medical Center, Israel	Completed	No outcome recorded
—	NCT02625181 Background	Jul 2016 → Nov 2017	—	Vanderbilt University	Completed	No outcome recorded
—	NCT03780556 Comparator	Jan 2016 → Jul 2017	urinary tract obstruction	Ain Shams University	Completed	No outcome recorded
—	NCT02393144 Background	Feb 2015 → Jan 2017	pregnancy disorder	Ankara University	Unknown	No outcome recorded
—	NCT02037802 Comparator	Mar → Oct 2014	kidney failure	Cairo University	Completed	No outcome recorded
—	NCT02016976 Comparator	Jan → Aug 2014	—	Hillel Yaffe Medical Center	Unknown	No outcome recorded
—	NCT02012244 Background	Jan → Dec 2014	colorectal cancer	Severance Hospital	Completed	No outcome recorded
—	NCT02039453 Comparator	Sep 2013 → Aug 2015	—	Yonsei University	Unknown	No outcome recorded
—	NCT01948921 Comparator	Sep 2013 → Mar 2017	—	Dalin Tzu Chi General Hospital	Completed	No outcome recorded
—	NCT01997788 Background	Aug → Oct 2013	renal cell carcinoma	Seoul National University Hospital	Completed	No outcome recorded
—	NCT01993589 Comparator	Nov 2012 → Nov 2013	—	Kayseri Education and Research Hospital	Completed	No outcome recorded
—	NCT00848861 Comparator	Feb → Jun 2006	—	University of Alberta	Completed	No outcome recorded
—	NCT00566683 Comparator	Jul 2005 → Jun 2006	—	North District Hospital	Completed	No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 92 sources stand behind the page.

Field	Value	Cited text
Known as	meperidine	“If the NRS score is ≥ 4, 0.5 mg kg-1 iv meperidine will be administered as a rescue analgesic.” NCT06546839 ↗ 46 “If the NRS score is ≥ 4, 0.5 mg kg-1 IV meperidine will be administered as a rescue analgesic.” NCT07278050 ↗ “If the NRS score is ≥ 4, 0.5 mg kg-1 iv meperidine will be administered as a rescue analgesic.” NCT05904912 ↗ “If the NRS score is ≥ 4, 0.5 mg kg-1 iv meperidine will be administered as a rescue analgesic.” NCT05972122 ↗ “Group P (n =80) will receive pethidine (meperidine) 0.5 mg/kg i.v. (Ampoules of 50 mg/1 ml).” NCT06627816 ↗ “Intravenous meperidine administration at 0.5 mg / kg rescue analgesia was determined” NCT03413163 ↗ “Hydroxyzine (1.5- 2mg/kg) + Meperidine (1.5 -2 mg/kg) + Midazolam (0.5- 0.75 mg/kg)” NCT05126459 ↗ “If the VAS score will be ≥ 4, 0,5 mg/kg-1 meperidine IV will be administered.” NCT05621161 ↗ “Meperidine 25-50 mg IVPB every 4 hours will be given as needed for rigors.” NCT03456817 ↗ “0.5 mg kg-1 iv meperidine will be administered as a rescue analgesic.” NCT06866054 ↗ “0.5 mg kg-1 iv meperidine will be administered as a rescue analgesic.” NCT05566561 ↗ Show 36 more sources
Known as	Demerol	ClinicalTrials.gov intervention name — accepted as the source's own label NCT01997788 ↗
Known as	pethidine	“Group P (n =80) will receive pethidine (meperidine) 0.5 mg/kg i.v. (Ampoules of 50 mg/1 ml).” NCT06627816 ↗ 44 “fentanyl based patient-controlled analgesia + additional pethidine for postoperative 48 hour” NCT02012244 ↗ “intravenous paracetamol( 1gram ) and pethidine IV (50 mg ) will be added when needed.” NCT03422354 ↗ “Postoperatively pethidine 50 mg IV will be administered for VAS score greater than 4” NCT07299630 ↗ “The forth group consisted of 25 participants receiving 100 mg pethidine.” NCT01993589 ↗ “then intravenous pethidine till 48 hours after surgery” NCT03866733 ↗ “Group P received pethidine 50 mg IV.” NCT03780556 ↗ “intravenous pethidine 0.25 mg/kg” NCT04133571 ↗ “"Meperidine" (pethidine®)” NCT02475824 ↗ NCT02619019 ↗ NCT04744727 ↗ Show 34 more sources
Known as	pethidine HCL	“Meperidine (50mg. 25mg for patients aged ≥70 years; pethidine HCL, Hana Pharm Co., Seoul, Republic of Korea).” NCT02475824 ↗
Known as	Pethidine Hydrochloride	“Pethidine Hydrochloride 50 Mg/mL Solution for Injection” NCT06775431 ↗ 2 NCT01558622 ↗ NCT01858090 ↗
Action	Activate	“Pethidine is one of the most frequently used opiate agonists.” NCT02783508 ↗
Modality	Small molecule	“synthetic opioid analgesic” NCT01558622 ↗
Route	Other	“continuous infusion of epidural pethidine through a surgically-placed catheter” NCT00163553 ↗