drugset / Trial / NCT05284409

Comparative Study Between the Prophylactic Intravenous Administrations of Acetaminophen vs Dexamethasone vs Pethidine Regarding the Incidence of Shivering Induced by Single Shot Spinal Anesthesia in the Orthopedic Surgeries of the Lower Limbs

NCT05284409

Phase 4 Completed 130 enrolled Ain Shams University
RandomizedParallel-groupDouble-blindSupportive care

Summary

Single Shot Spinal anesthesia (SSSA) is associated with considerable perioperative shivering and can be challenging to treat. Some pharmacologic agents like N-methyl d-aspartate receptor antagonists, magnesium sulfate and opioid analgesics have been used for restriction of post-spinal anesthesia shivering. Besides that shivering is poorly understood, the gold standard for the treatment and prevention has not been defined yet. This study is to determine the effect of prophylactic intravenous administration of acetaminophen versus dexamethasone versus pethidine in controlling shivering induced by spinal anesthesia

Timeline

Start
2022-07-01
Primary completion
2022-09-20
Completion
2022-10-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Acetaminophen Small molecule 15 mg/kg Intravenous
Subject Dexamethasone Small molecule 0.1 mg/kg Intravenous
Comparator Meperidine Unknown 0.5 mg/kg Intravenous