Effect of Cobicistat Versus Ritonavir Boosting on the Brain Permeation of Darunavir in HIV-infected Individuals

Phase 4 Terminated 7 enrolled University Hospital, Basel, Switzerland

NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to assess whether a boosting by cobicistat results in similar concentrations of darunavir in the brain compared to a boosting by ritonavir.

Timeline

Start: 2015-07
Primary completion: 2017-01
Completion: 2017-01

Outcome

Outcome not reported

Stopped: “No additional patients fulfilling the inclusion criteria”

Publications

Bartels H, Decosterd L, Battegay M, Marzolini C. Darunavir concentrations in CSF of HIV-infected individuals when boosted with cobicistat versus ritonavir. J Antimicrob Chemother. 2017 Sep 1;72(9):2574-2577. doi: 10.1093/jac/dkx165.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cobicistat	Small molecule	150 mg	—
Subject	Darunavir	Small molecule	800 mg	—
Subject	Ritonavir	Other / unclassified	100 mg	—