Fatty Acid Oxidation Defects and Insulin Sensitivity
Summary
The purpose of this study is to learn more about what causes insulin resistance. It has been suggested that proper breakdown of fat into energy (oxidation) in the body is important to allow insulin to keep blood sugar in the normal range. The investigators want to know if having one of the fatty acid oxidation disorders could have an influence on insulin action. Fatty acid oxidation disorders are genetic disorders that inhibit one of the enzymes that converts fat into energy. The investigators will study both normal healthy people and people with a long-chain fatty acid oxidation disorder.
Timeline
- Start
- 2016-02
- Primary completion
- 2021-01
- Completion
- 2021-03
Outcome
Missed primary endpoint
registry analysis (other test); Glycerol/Saline FAOD vs Intralipid FAOD vs Glycerol/Saline Control vs Intralipid Control; p = 0.136; Mixed Models Analysis NCT02517307 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Glycerol | Small molecule | — | — |
| Subject | Intralipid | Other / unclassified | — | — |
| Background | Heparin | Other / unclassified | — | — |