drugset / Trial / NCT02527083

Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain

NCT02527083 ↗

Phase 4 Completed 10 enrolled VA Pittsburgh Healthcare System
RandomizedParallel-groupSingle-blindPrevention

Summary

Research suggests that the type of anesthesia used for surgery may affect intraoperative stress hormone levels. There is also data to support that an increased level of stress hormones leads to increased pain after surgery. The primary aim of this study is to determine the effect of anesthesia type on long term pain after hernia surgery. In this study, patients undergoing inguinal hernia repair will be randomized to an anesthetic group, either Total Intravenous Anesthesia (TIVA) maintained with propofol or Balanced Inhaled Anesthesia (BIA) maintained with sevoflurane. This will allow us to look at any differences in short and long-term pain after hernia repair depending on type of anesthesia received.

Timeline

Start
2015-01
Primary completion
2019-06
Completion
2019-06

Drugs

EvaluationDrugModalityDoseRoute
Comparator Ketamine Small molecule — Intravenous
Comparator Propofol Small molecule — Intravenous
Comparator Remifentanil Small molecule — Intravenous
Comparator Sevoflurane Other / unclassified — Inhaled

Indications