Midazolam Used Alone or Sequential Use of Midazolam and Propofol/Dexmedetomidine in Mechanically Ventilated Patients

Phase 4 Unknown 240 enrolled West China Hospital

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study was to evaluate effects, safety and cost of midazolam used alone or sequential use of midazolam and propofol/dexmedetomidine for long-term sedation in critically ill, mechanically ventilated patients.

Timeline

Start: 2015-12
Primary completion: 2016-12
Completion: 2017-02

Publications

Zhou Y, Yang J, Wang B, Wang P, Wang Z, Yang Y, Liang G, Jing X, Jin X, Zhang Z, Deng Y, Hu C, Liao X, Yin W, Tang Z, Tian Y, Tao L, Kang Y. Sequential use of midazolam and dexmedetomidine for long-term sedation may reduce weaning time in selected critically ill, mechanically ventilated patients: a randomized controlled study. Crit Care. 2022 May 3;26(1):122. doi: 10.1186/s13054-022-03967-5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	0.2 ug/kg	—
Subject	Dexmedetomidine	Other / unclassified	0.7 ug/kg	—
Subject	Midazolam	Small molecule	0.03 mg/kg	—
Subject	Midazolam	Small molecule	0.2 mg/kg	—
Subject	Propofol	Small molecule	0.5 mg/kg	—
Subject	Propofol	Small molecule	3 mg/kg	—
Background	Fentanyl	Other / unclassified	1 ug/kg	—
Background	Fentanyl	Other / unclassified	2 ug/kg	—

Midazolam Used Alone or Sequential Use of Midazolam and Propofol/Dexmedetomidine in Mechanically Ventilated Patients

Summary

Timeline

Publications

Drugs

Indications