drugset / Trial / NCT02631239

MESA Versus ESA in the Treatment of Early Stage NK/T-cell Lymphoma

NCT02631239

Phase 3 Unknown 256 enrolled Ruijin Hospital
RandomizedParallel-groupOpen-labelTreatment

Summary

Extranodal natural killer (NK)/T-cell lymphoma (ENKTL), nasal type, is a distinct and heterogeneous histopathologic subtype of non-Hodgkin lymphoma (NHL), accounting for 5%\~10%. The frequency of ENKTL among NHL patients is significantly higher in Asia than in Western countries, with poor prognosis. Radiotherapy plus chemotherapy has improved the survival for these patients. But the optimal treatment schedule is controversial. The previous protocols usually contained high dose methotrexate, but the application of them is limited for the toxicity.

Timeline

Start
2016-03-16
Primary completion
2021-03-05
Completion
2022-07-17

Drugs

EvaluationDrugModalityDoseRoute
Comparator Methotrexate Small molecule 1 unknown Intravenous
Background Dexamethasone Small molecule 40 mg Oral
Background Etoposide Small molecule 200 mg Oral
Background Pegaspargase Protein / enzyme biologic 2500 unknown Intramuscular