drugset / Trial / NCT02631239
MESA Versus ESA in the Treatment of Early Stage NK/T-cell Lymphoma
RandomizedParallel-groupOpen-labelTreatment
Summary
Extranodal natural killer (NK)/T-cell lymphoma (ENKTL), nasal type, is a distinct and heterogeneous histopathologic subtype of non-Hodgkin lymphoma (NHL), accounting for 5%\~10%. The frequency of ENKTL among NHL patients is significantly higher in Asia than in Western countries, with poor prognosis. Radiotherapy plus chemotherapy has improved the survival for these patients. But the optimal treatment schedule is controversial. The previous protocols usually contained high dose methotrexate, but the application of them is limited for the toxicity.
Timeline
- Start
- 2016-03-16
- Primary completion
- 2021-03-05
- Completion
- 2022-07-17
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Methotrexate | Small molecule | 1 unknown | Intravenous |
| Background | Dexamethasone | Small molecule | 40 mg | Oral |
| Background | Etoposide | Small molecule | 200 mg | Oral |
| Background | Pegaspargase | Protein / enzyme biologic | 2500 unknown | Intramuscular |