drugset / Trial / NCT02734966
Efficacy and Safety Study of Magnesium Isoglycyrrhizinate Injection in Subjects With Acute Drug-induced Liver Injury
RandomizedParallel-groupQuadruple-blindTreatment
Summary
The purpose of this study is to investigate the safety, effective dosage and treatment of Magnesium Isolycyrrhizinate Injection to cure the acute drug-induced liver injury compared with the Tiopronin Injection.
Timeline
- Start
- 2007-12
- Primary completion
- 2008-12
- Completion
- 2011-12
Publications
- Background Maria VA, Victorino RM. Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis. Hepatology. 1997 Sep;26(3):664-9. doi: 10.1002/hep.510260319.
- Background Watkins PB, Seeff LB. Drug-induced liver injury: summary of a single topic clinical research conference. Hepatology. 2006 Mar;43(3):618-31. doi: 10.1002/hep.21095.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Magnesium Isoglycyrrhizinate | Unknown | 100 mg | — |
| Subject | Magnesium Isoglycyrrhizinate | Unknown | 200 mg | — |
| Comparator | Tiopronin | Small molecule | 200 mg | — |