drugset / Trial / NCT02736032
Cryopreserved-thawed Embryo Transfer With or Without Gonadotropin Releasing Hormone Agonist
Phase 3
Completed
310 enrolled
Cairo University
Kamal Shaeer center of infertility · collabNile Ivf Center, Cairo, Egypt · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
Traditionally, the use of GnRH-a suppression was considered essential for adequate endometrial hormonal modulation in cryopreserved-thawed embryo transfer cycles. Several studies, however, have questioned its necessity for controlled endometrial preparation. Using a high dose of estradiol from day 1 of the cycle will suppress the gonadotroph, preventing folliculogenesis and excessive secretion of LH, allowing adequate endometrial preparation without GnRH-a.
Timeline
- Start
- 2016-03
- Primary completion
- 2018-05
- Completion
- 2018-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Decapeptyl SR | Unknown | — | — |
| Comparator | Estradiol | Other / unclassified | 6 mg | — |
| Comparator | Estradiol | Other / unclassified | 8 mg | — |
| Comparator | Progesterone | Other / unclassified | 800 mg | Other |