Anesthetic Depth Effects Upon Immune Competent Cells

Completed 16 enrolled Heidelberg University

RandomizedParallel-groupTriple-blindTreatment

Summary

Anesthesia depth affects the proliferation of lymphocytes to NK-cells and memory T-cells effect and the phagocytosis activity of macrophages in healthy patients. ASA 1-3 subjects undergoing extended shoulder surgery under continuous regional anesthesia randomly were assigned to a deep or a shallow anesthesia level (BIS \<35 or \>55) for more than an hour. Immune response is measured by lymphocyte proliferation as well as neutrophil and monocyte phagocytosis activity.

Timeline

Start: 2009-03
Primary completion: 2012-03
Completion: 2013-03

Publications

Nguyen XD, Horn A, Fischer D, Beck G, Spannenberger CC, Gaudilliere B, Horn JL, Thierse HJ, Frietsch T. Suppressive effects of deep balanced anesthesia on cellular immunity and protein expression: a randomized-controlled pilot study. BMC Anesthesiol. 2025 Mar 17;25(1):129. doi: 10.1186/s12871-025-02980-9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Fentanyl	Other / unclassified	—	—
Subject	Propofol	Small molecule	—	—
Subject	Sevoflurane	Other / unclassified	—	—

Indications

No indication recorded.