drugset / Trial / NCT02837614

Evaluation of Preoperative Submucosal Dexamethasone in Third Molar Surgery

NCT02837614

Phase 0 Completed 60 enrolled Sun Yat-sen University
RandomizedParallel-groupOpen-labelTreatment

Summary

The study composed of sixty patients, each of whom required surgical extraction of a single impacted mandibular third molar under local anaesthesia. The patients were randomly allocated to one of 3 groups of 20 each. The three groups were categorized as Group A (intramuscular dexamethasone), Group B (submucosal dexamethasone) and Group C (control). The objective measurements of facial pain, swelling, and trismus was performed by an independent examiner at baseline (preoperatively), and at days 1, 3, and 7 postoperatively.

Timeline

Start
2015-10
Primary completion
2016-01
Completion
2016-03

Drugs

EvaluationDrugModalityDoseRoute
Comparator Dexamethasone Small molecule 4 mg Intramuscular
Background Acetaminophen Small molecule 500 mg
Background Amoxicillin Other / unclassified 500 mg Oral