drugset / Trial / NCT02845596
Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia
RandomizedParallel-groupOpen-labelOther
Summary
The purpose of this study is to determine the feasibility of comparing outcomes of patients treated de novo with immunosuppressive therapy (IST) versus matched unrelated donor (MUD) hematopoietic stem cell transplant (HSCT) for pediatric acquired severe aplastic anemia.
Timeline
- Start
- 2016-08
- Primary completion
- 2020-11-03
- Completion
- 2023-07-19
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | ANTILYMPHOCYTE IMMUNOGLOBULIN (HORSE) | Protein / enzyme biologic | — | — |
| Comparator | Cyclophosphamide | Other / unclassified | — | — |
| Comparator | Cyclosporine | Peptide | — | — |
| Comparator | Fludarabine | Small molecule | — | — |
| Comparator | Methotrexate | Small molecule | — | — |
| Comparator | Thymoglobulin | Protein / enzyme biologic | — | — |