Drugs / Thymoglobulin
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Thymoglobulin

Protein / enzyme biologic

Developed for
myelodysplastic syndrome · acute myeloid leukemia · transplant rejection · aplastic anemia · chronic myeloid leukemia · hematopoietic and lymphoid cell neoplasm · graft versus host disease · leukemia
+22 more · acute lymphoblastic leukemia · cancer · chronic lymphocytic leukemia/small lymphocytic lymphoma · diabetes mellitus · Hodgkins lymphoma · kidney failure · plasma cell myeloma · acquired aplastic anemia · acute graft versus host disease · acute transplant rejection · autosomal genetic disease · end stage renal failure · engraftment syndrome · immunodeficiency disease · liver failure · metabolic disease · neuroblastoma · refractory plasma cell neoplasm · systemic sclerosis · Wiskott-Aldrich syndrome · impaired renal function disease · ischemic disease
Investigated by
Genzyme, a Sanofi Company · M.D. Anderson Cancer Center · The Korean Society of Pediatric Hematology Oncology · Peking University People's Hospital · University of Miami · Washington University School of Medicine
+47 more · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Novartis · Sanofi · The Cleveland Clinic · Amgen · Ann & Robert H Lurie Children's Hospital of Chicago · Barbara Ann Karmanos Cancer Institute · Belgian Hematological Society · Brigham and Women's Hospital · Columbia University · Coordinación de Investigación en Salud, Mexico · Emory University · Georgetown University · Hoffmann-La Roche · Hospices Civils de Lyon · Hospital Geral de Fortaleza · Hospital de Santa Maria, Portugal · Hospital do Rim e Hipertensão · Institut Paoli-Calmettes · Instituto de Investigación Hospital Universitario La Paz · Johns Hopkins University · Lahey Clinic · Masonic Cancer Center, University of Minnesota · Ministry of Health, France · Nagoya University · Nantes University Hospital · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) · Providence Health & Services · Roche Pharma AG · St. Jude Children's Research Hospital · St. Paul's Hospital, Canada · St. Petersburg State Pavlov Medical University · Swedish Medical Center · The Hospital for Sick Children · The Methodist Hospital Research Institute · Unity Health Toronto · University Health Network, Toronto · University Hospital, Brest · University Hospital, Clermont-Ferrand · University of Arizona · University of Liege · University of Nebraska · University of Pittsburgh · Vastra Gotaland Region · Virginia Commonwealth University · Wake Forest University · Wright State University

Trials 56

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 14 trials
Phase 1 NCT07052370 Sep 2025 → Dec 2028 expected hematopoietic and lymphoid system neoplasm St. Jude Children's Research Hospital Recruiting No outcome recorded
Phase 1 NCT00545519 Oct 2006 → Mar 2008 refractory plasma cell neoplasm Washington University School of Medicine Completed No outcome recorded
Phase 1 NCT00670410 Nov 2003 → Dec 2010 neuroblastoma Columbia University Terminated No outcome recorded Stop: Enrollment
Phase 1 NCT00040651 Jul 2002 → Mar 2007 systemic sclerosis National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Terminated No outcome recorded
Phase 1/24 trials
Phase 1/2 NCT00679536 May 2008 → May 2015 leukemia Ann & Robert H Lurie Children's Hospital of Chicago Unknown No outcome recorded
Phase 1/2 NCT00885833 Feb 2007 → Mar 2012 Wiskott-Aldrich syndrome The Korean Society of Pediatric Hematology Oncology Completed No outcome recorded
Phase 1/2 NCT00409695 Dec 2006 → Aug 2007 acute graft versus host disease M.D. Anderson Cancer Center Terminated No outcome recorded Stop: Enrollment
Phase 1/2 NCT00887042 Jun 2006 → May 2012 acute myeloid leukemia The Korean Society of Pediatric Hematology Oncology Unknown No outcome recorded
Phase 226 trials · 1 met primary · 2 missed
Phase 2 NCT06872333 Nov 2024 → Jun 2030 expected disease related to hematopoietic stem cell transplant, sickle cell disease Masonic Cancer Center, University of Minnesota Recruiting No outcome recorded
Phase 2 NCT06066255 Mar 2024 → Mar 2026 hematopoietic and lymphoid cell neoplasm Institut Paoli-Calmettes Unknown No outcome recorded
Phase 2 NCT03852407 Feb 2019 → Nov 2033 expected Hodgkins lymphoma, acute lymphoblastic leukemia, acute myeloid leukemia, chronic myeloid leukemia +2 University of Liege Recruiting No outcome recorded
Phase 2 NCT02877082 Sep 2016 → Jul 2017 chronic lymphocytic leukemia/small lymphocytic lymphoma, chronic myeloid leukemia, diffuse large B-cell lymphoma, follicular lymphoma +5 Emory University Terminated No outcome recorded
Phase 2 NCT02544113 Dec 2015 → Jun 2018 liver failure The Cleveland Clinic Completed Missed primary
Phase 2 NCT02627573 Jul 2015 → Apr 2019 atypical chronic myeloid leukemia, BCR-ABL1 negative, chronic myeloid leukemia, myelodysplastic syndrome St. Petersburg State Pavlov Medical University Terminated No outcome recorded Stop: Enrollment
Phase 2 NCT01556347 Jul 2012 → May 2016 — Providence Health & Services Terminated No outcome recorded
Phase 2 NCT01566656 Mar 2012 → Nov 2016 hematopoietic and lymphoid cell neoplasm Nantes University Hospital Completed No outcome recorded
Phase 2 NCT01246206 Nov 2010 → Oct 2013 hematopoietic and lymphoid cell neoplasm Barbara Ann Karmanos Cancer Institute Completed No outcome recorded
Phase 2 NCT01939171 Jun 2010 → Feb 2012 — Instituto de Investigación Hospital Universitario La Paz Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT03793517 Sep 2018 → Oct 2023 overdue acute myeloid leukemia, disease related to hematopoietic stem cell transplant Peking University People's Hospital Recruiting No outcome recorded
Phase 33 trials
Phase 3 NCT01844635 May 2012 → May 2016 acquired aplastic anemia Nagoya University Unknown No outcome recorded
Phase 3 NCT01028092 Mar 2009 → Mar 2014 — University Hospital, Brest Completed No outcome recorded
Phase 3 NCT00275509 Jan 2007 → Jun 2010 chronic renal failure syndrome Johns Hopkins University Completed No outcome recorded
Phase 411 trials · 2 met primary · 1 missed
Phase 4 NCT05743400 Sep 2023 → Apr 2025 overdue thrombotic microangiopathy Hospices Civils de Lyon Recruiting No outcome recorded
Phase 4 NCT03006419 Dec 2016 → Jul 2019 transplant rejection Coordinación de Investigación en Salud, Mexico Completed No outcome recorded
Phase 4 NCT03088280 Jun 2015 → Jan 2018 — Hospital Geral de Fortaleza Unknown No outcome recorded
Phase 4 NCT01856803 Oct 2013 → Jun 2018 graft versus host disease Peking University People's Hospital Completed Met primary
Phase 4 NCT02083991 Jan 2013 → Jan 2017 diabetes mellitus Vastra Gotaland Region Completed No outcome recorded
Phase 4 NCT01354301 May 2011 → Apr 2014 cytomegalovirus infection, transplant rejection Hospital do Rim e Hipertensão Completed Met primary
Phase 4 NCT01149993 Jun 2010 → Jun 2012 — Georgetown University Withdrawn No outcome recorded
Phase 4 NCT00706680 Feb 2008 → Feb 2009 diabetes mellitus, transplant rejection University Health Network, Toronto Unknown No outcome recorded
Phase 4 NCT01172418 Feb 2006 → May 2010 — University of Miami Completed Missed primary
Phase 4 NCT00685061 Nov 2002 → Sep 2004 — University of Miami Completed No outcome recorded
Phase not applicable7 trials · 1 met primary
— NCT03821987 Dec 2018 → Dec 2021 aplastic anemia, engraftment syndrome Peking University People's Hospital Unknown No outcome recorded
— NCT01280617 Oct 2010 → Nov 2013 acute kidney injury Lahey Clinic Completed Met primary
— NCT00970073 Aug 2009 → Jun 2015 — The Cleveland Clinic Completed No outcome recorded
— NCT00714480 Jul 2008 → Dec 2009 immunodeficiency disease Swedish Medical Center Completed No outcome recorded
— NCT00476229 Jun 2006 → May 2009 leukemia, lymphoma M.D. Anderson Cancer Center Completed No outcome recorded
— NCT00235781 Jan → Feb 2006 — Washington University School of Medicine Terminated No outcome recorded
— NCT00088543 Mar 2004 → Apr 2006 acute lymphoblastic leukemia, acute myeloid leukemia, graft versus host disease Genzyme, a Sanofi Company Completed No outcome recorded
Comparator or background therapy59 trials
Phase 1 NCT05298358 Background Nov 2022 → Nov 2024 systemic sclerosis Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Terminated No outcome recorded Stop: Enrollment
Phase 1 NCT02512497 Background Dec 2017 → Oct 2023 T-cell large granular lymphocyte leukemia, T-cell prolymphocytic leukemia, peripheral T-cell lymphoma, not otherwise specified, primary cutaneous T-cell lymphoma Ohio State University Comprehensive Cancer Center Completed No outcome recorded
Phase 1 NCT02867800 Background Jul 2016 → Dec 2021 graft versus host disease, sickle cell disease Monica Bhatia Completed No outcome recorded
Phase 1 NCT00402558 Background May 2006 → Apr 2014 leukemia, myelodysplastic syndrome M.D. Anderson Cancer Center Completed No outcome recorded
Phase 1 NCT00669890 Background May 2004 → Dec 2012 acute myeloid leukemia, juvenile myelomonocytic leukemia, myelodysplastic syndrome New York Medical College Terminated No outcome recorded

Evidence & citations 21 cited values

Every value below carries the sentence it was read from. 118 sources stand behind the page.

FieldValueCited text
Known as Thymoglobulin “A Study to Compare the Effectiveness of a Drug That Suppresses the Immune System Called Thymoglobulin® in Preventing the Development of a Disease That Affects the Majority of...” NCT01157949 ↗
117

“A prominent example of this class of drugs is Thymoglobulin(TMG), a purified, pasteurized gamma immune globulin, which is obtained by immunization of rabbits with human thymocytes.” NCT00714480 ↗

“At our institution, one such antibody preparation (Thymoglobulin) is used in most pediatric heart transplant recipients for 3-5 days immediately after transplantation.” NCT00709293 ↗

“Children over two years and adults undergoing a first hematopoietic stem cell transplantation will receiveThymoglobulin® as part of the conditioning.” NCT05743400 ↗

“All patients will start with Thymoglobulin 1 mg/kg before transplant followed by 0,5 mg/kg/d during the next 5 days (total accumulated 3,5 mg/kg).” NCT01195194 ↗

“Two randomized groups of kidney transplant recipients will be each administered the drug Thymoglobulin according to a different dosing regimen.” NCT00906204 ↗

“ATG: Thymoglobulin will be administered five times intravenously at 1.5 mg/kg/day from day -11 through day -7 for a total dose of 7.5 mg/kg.” NCT01566656 ↗

“The two commonly used ATGs, Thymoglobulin and ATG-F have slightly different antigen profile and antibody concentrations.” PMID 27855166 ↗ Nov 2016

“Patients receive immunosuppressive induction treatment with thymoglobulin (at least 1 dose and maximum of 5 doses)” NCT07203664 ↗

“Conditioning regimen Thymoglobulin (0.5/mg/kg à D-9, 2 mg /kg at D-8 and 2.5 mg/kg à D-7)” NCT06646497 ↗

“Thymoglobulin Versus Alemtuzumab Versus Daclizumab in Living Donor Renal Transplantation” NCT01046955 ↗

Show 107 more sources

Known as anti thymoglobulin “Drug: anti thymoglobulin” NCT01856803 ↗
Known as Anti-Thymocyte Globulin (Rabbit) “Thymoglobulin [Anti-Thymocyte Globulin (Rabbit)]” NCT00088543 ↗
1

“Thymoglobulin [Anti-Thymocyte Globulin (Rabbit)]” NCT00089947 ↗

Known as anti-thymocyte globulin (rabbit), thymoglobulin “anti-thymocyte globulin (rabbit), thymoglobulin” NCT00771745 ↗
Known as antithymocyte globulin “Rabbit antithymocyte globulin (rATG, Thymoglobulin®) is the most common induction immunosuppression therapy in kidney transplantation.” PMID 26285695 ↗ Aug 2015
3

“comparing antithymocyte globulin (Thymoglobulin) (group A, N=43) versus alemtuzumab (group B, N=43) versus daclizumab (group C, N=42)” PMID 24477186 ↗ Jun 2014

“Thymoglobulin, rabbit derived antithymocyte globulin (Thymoglobulin, SangStat, Fremont, CA)” NCT00235781 ↗

“Thymoglobulin (anti-thymocyte globulin)” NCT01149993 ↗

Known as ATG “rabbit anti-thymocyte globulin (ATG) (Thymoglobuline, Genzyme)” NCT01844635 ↗
3

“ATG (thymoglobulin; Sang Stat, France)” NCT03799224 ↗

“Thymoglobulin (ATG)” NCT00469014 ↗

“ATG” NCT01490723 ↗

Known as rabbit anti-thymocyte globulin “Rabbit antithymocyte globulin (rATG, Thymoglobulin®) is the most common induction immunosuppression therapy in kidney transplantation.” PMID 26285695 ↗ Aug 2015
2

“Thymoglobulin (rabbit antithymocyte globulin) is FDA approved for the treatment of acute cellular rejection.” NCT01280617 ↗

“rabbit anti-thymocyte globulin (ATG) (Thymoglobuline, Genzyme)” NCT01844635 ↗

Known as rabbit anti-thymocyte globulin (ATG) “Thymoglobulin® (Genzyme) \[rabbit anti-thymocyte globulin (ATG)\]” NCT03292861 ↗
Known as Rabbit Anti-thymocyte Globulin (rATG) “Thymoglobulin®, Rabbit Anti-thymocyte Globulin (rATG)” NCT00542828 ↗
Known as rabbit Thymoglobulin (r-ATG) “rabbit Thymoglobulin (r-ATG)” NCT02084446 ↗
Known as rabbitATG “The patient will also receive Thymoglobulin (rabbitATG) on Day -4 to Day -2.” NCT00679536 ↗
Known as rATG “Rabbit antithymocyte globulin (rATG, Thymoglobulin®) is the most common induction immunosuppression therapy in kidney transplantation.” PMID 26285695 ↗ Aug 2015
2

“thymoglobulin (A :rATG ,Sang Stat,France) 2.5mg/kg/dx4d” NCT03821987 ↗

“rabbit Thymoglobulin (rATG)” NCT07607197 ↗

Known as rATG (rabbit antithymocyte globulin) “rATG (rabbit antithymocyte globulin)” NCT01172418 ↗
Known as Sang Stat “thymoglobulin (A :rATG ,Sang Stat,France) 2.5mg/kg/dx4d” NCT03821987 ↗
Known as Thymo-S “All patients received rATG for 4 days [ATG-Fresenius (ATG-F) 4 mg/kg/day or Thymoglobulin (Thymo-S) 1.25 mg/kg/day] plus MMF and short-term corticosteroids.” PMID 15814548 ↗ May 2005
Known as Thymoglobulin, Genzyme “Thymoglobulin, Genzyme” NCT00682292 ↗
Known as Thymoglobuline “rabbit anti-thymocyte globulin (ATG) (Thymoglobuline, Genzyme)” NCT01844635 ↗
Known as TMG “A prominent example of this class of drugs is Thymoglobulin(TMG), a purified, pasteurized gamma immune globulin, which is obtained by immunization of rabbits with human thymocytes.” NCT00714480 ↗
Action Deplete “thymoglobulin to kill the T-cells” NCT00040651 ↗
Modality Protein / enzyme biologic “a FDA-approved polyclonal rabbit-IgG antithymocyte preparation” NCT00006178 ↗
Route Intravenous “Thymoglobulin will be given intravenously” NCT00006178 ↗