drugset / Trial / NCT02872818
Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia
RandomizedParallel-groupTriple-blindTreatment
Summary
The purpose of the study is to determine apoptotic signaling pathways such as Survivin, Bcl-2, Bax, c-Myc and caspase-9 expression levels in rats model with iatrogenic endometrial hyperplasia after metformin and medroxyprogesterone acetate administration.
Timeline
- Start
- 2014-10
- Primary completion
- 2015-03
- Completion
- 2015-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Metformin | Small molecule | 50 mg/kg | — |
| Comparator | medroxyprogesterone acetate | Other / unclassified | 1 mg/kg | — |
| Comparator | Estradiol | Other / unclassified | 4 mg/kg | — |