Effect of Wound Infiltration by Ketamine Versus Dexmedetomidine Added to Bupivacaine on Surgical Stress

Phase 3 Completed 90 enrolled Assiut University

RandomizedParallel-groupDouble-blindHealth-services research

Summary

This study aims to compare the effects of local wound infiltration with ketamine versus dexmedetomidine when added to bupivacaine on stress response and postoperative pain in lower abdominal cancer surgery.

Timeline

Start: 2016-06
Primary completion: 2016-12
Completion: 2017-10

Publications

Mohamed SA, Sayed DM, El Sherif FA, Abd El-Rahman AM. Effect of local wound infiltration with ketamine versus dexmedetomidine on postoperative pain and stress after abdominal hysterectomy, a randomized trial. Eur J Pain. 2018 May;22(5):951-960. doi: 10.1002/ejp.1181. Epub 2018 Feb 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Dexmedetomidine	Other / unclassified	1 ug/kg	Other
Comparator	Ketamine	Small molecule	1 mg/kg	Other
Comparator	Bupivacaine	Other / unclassified	0.5 %	Other
Comparator	Bupivacaine	Other / unclassified	20 ml	Other

Effect of Wound Infiltration by Ketamine Versus Dexmedetomidine Added to Bupivacaine on Surgical Stress

Summary

Timeline

Publications

Drugs

Indications