Neoadjuvant Chemotherapy With SEEOX Regimen for Borrmann Type 4 Gastric Cancer

Phase 2 Unknown 40 enrolled Jinling Hospital, China

NaSingle-groupOpen-labelTreatment

Summary

Scirrhous gastric cancer, also known as linitis plastic or Borrmann type 4, is an aggressive tumor with an extremely poor prognosis. Aggressive surgical procedures and adjuvant chemotherapies have not improved the survival rate. The purpose of this study is to determine whether neoadjuvant Chemotherapy with SEEOX regimen via intra-arterial and intravenous administration are effective in the treatment of Borrmann type 4 gastric cancer.

Timeline

Start: 2017-01
Primary completion: 2019-01
Completion: 2021-01

Publications

Xiang XS, Su Y, Li GL, Ma L, Zhou CS, Ma RF. Phase II Study of Preoperative Intra-Arterial Epirubicin, Etoposide, and Oxaliplatin Combined with Oral S-1 Chemotherapy for the Treatment of Borrmann Type 4 Gastric Cancer. J Gastric Cancer. 2020 Dec;20(4):395-407. doi: 10.5230/jgc.2020.20.e40. Epub 2020 Dec 29.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Epirubicin	Small molecule	30 mg	Other
Subject	Etoposide	Small molecule	100 mg	Other
Subject	Oxaliplatin	Small molecule	150 mg	Other
Subject	S-1	Small molecule	120 mg	Oral

Neoadjuvant Chemotherapy With SEEOX Regimen for Borrmann Type 4 Gastric Cancer

Summary

Timeline

Publications

Drugs

Indications