drugset / Trial / NCT02954484
Outcomes Of Perioperative Pregabalin On Total Knee Arthroplasty
RandomizedParallel-groupQuadruple-blindTreatment
Summary
This study aims to provide high quality evidence from a double-blinded, randomized controlled trial on the efficacy of perioperative pregabalin in reducing morphine requirements, improving pain scores and reducing chronic neuropathic pain when compared with placebo for primary total knee arthroplasty. It hence aims to improve on choice of analgesia adjuncts for total knee arthroplasty.
Timeline
- Start
- 2015-04
- Primary completion
- 2017-05
- Completion
- 2017-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Pregabalin | Small molecule | 75 mg | Oral |
| Comparator | Acetaminophen | Small molecule | 1 g | Oral |
| Comparator | Etoricoxib | Small molecule | 120 mg | Oral |
| Comparator | Morphine | Other / unclassified | — | Intravenous |
| Comparator | Ropivacaine | Other / unclassified | 0.5 % | — |
| Comparator | Ropivacaine | Other / unclassified | 30 ml | — |