Rebound Pain After Operations for Distal Radius Fractures With a Volar Plate in Brachial Plexus Block

NCT03011905 ↗

Phase 3 Completed 53 enrolled Oslo University Hospital

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Many patients have strong pain at brachial plexus block resolution after operations for distal radius fractures with a volar plate. This study investigates if a single dose of dexamethasone in addition to a standard pain regime have an effect on postoperative pain. The primary endpoint is difference in the highest pain score first 24 hours after surgery. The investigators will also look at pain scores and analgesics consumption first few hours after surgery and at different times up to 2 years after surgery.

Timeline

Start: 2017-01
Primary completion: 2019-04-05
Completion: 2020-04-05

Outcome

Met primary endpoint

paper was 4 (2-6 [0-7]) in the dexamethasone group compared with 8 (5-8 [2-10]) in the placebo group (p < 0.001). PMID 32472958 ↗

Publications

Holmberg A, Hassellund SS, Draegni T, Nordby A, Ottesen FS, Gulestol A, Raeder J. Analgesic effect of intravenous dexamethasone after volar plate surgery for distal radius fracture with brachial plexus block anaesthesia: a prospective, double-blind randomised clinical trial. Anaesthesia. 2020 Nov;75(11):1448-1460. doi: 10.1111/anae.15111. Epub 2020 May 30.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexamethasone	Small molecule	16 mg	Intravenous
Background	Acetaminophen	Small molecule	—	—
Background	Etoricoxib	Small molecule	—	—
Background	Oxycodone	Other / unclassified	—	Intravenous
Background	Ropivacaine	Other / unclassified	7.5 mg/ml	—