drugset / Trial / NCT03012971
Dexmedetomidine Supplemented Analgesia and Long-term Survival After Cancer Surgery
Completed
1500 enrolled
Peking University First Hospital
Affiliated Hospital of Hebei University · collabChongqing University Fuling Hospital · collabGuizhou Provincial People's Hospital · collabPeking University International Hospital · collabQingdao Municipal Hospital · collabShanxi Province Cancer Hospital · collabThe Second Affiliated Hospital of Air Force Military Medical University · collabThe Third Central Hospital of Tianjin · collabThe Third Xiangya Hospital of Central South University · collabTianjin Hospital of ITCWM-Nankai Hospital · collabXiyuan Hospital of China Academy of Chinese Medical Sciences · collab
RandomizedParallel-groupQuadruple-blindPrevention
Summary
A majority of the elderly patients undergo surgery for malignant tumors. For these patients, postoperative tumor recurrence and metastasis are main factors that worsen long-term outcomes. The investigators hypothesize that dexmedetomidine supplemented analgesia in elderly patients after cancer surgery may help to maintain immune function and improve long-term outcomes, possibly by relieving stress and inflammatory response, improving analgesic efficacy and sleep quality, and reducing delirium incidence.
Timeline
- Start
- 2017-01-06
- Primary completion
- 2024-12-11
- Completion
- 2024-12-11
Publications
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Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexmedetomidine | Other / unclassified | 1.25 ug/ml | Intravenous |
| Comparator | Morphine | Other / unclassified | 0.5 mg/ml | Intravenous |
Indications
No indication recorded.